T0901317
T0901317 structure
|
Common Name | T0901317 | ||
|---|---|---|---|---|
| CAS Number | 293754-55-9 | Molecular Weight | 481.333 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 470.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H12F9NO3S | Melting Point | 116-122° C | |
| MSDS | USA | Flash Point | 238.4±31.5 °C | |
|
Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport.
J. Nutr. Biochem. 26(2) , 165-72, (2015) High-density lipoproteins (HDLs) are atheroprotective because of their role in reverse cholesterol transport. The intestine is involved in this process because it synthesizes HDL, removes cholesterol from plasma and excretes it into the lumen. We investigated... |
|
|
RNA binding protein HuR regulates the expression of ABCA1.
J. Lipid Res. 55(6) , 1066-1076, (2014) ABCA1 is a major regulator of cellular cholesterol efflux and plasma HDL biogenesis. Even though the transcriptional activation of ABCA1 is well established, the posttranscriptional regulation of ABCA1 expression is poorly understood. Here, we investigate the... |
|
|
Effect of compounds affecting ABCA1 expression and CETP activity on the HDL pathway involved in intestinal absorption of lutein and zeaxanthin.
Lipids 49(12) , 1233-43, (2014) The antioxidant xanthophylls lutein and zeaxanthin are absorbed from the diet in a process involving lipoprotein formation. Selective mechanisms exist for their intestinal uptake and tissue-selective distribution, but these are poorly understood. We investiga... |
|
|
Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.
J. Pharmacol. Exp. Ther. 354 , 376-83, (2015) Previous studies demonstrated that liver X receptor (LXR) agonists inhibit human immunodeficiency virus (HIV) replication by upregulating cholesterol transporter ATP-binding cassette A1 (ABCA1), suppressing HIV production, and reducing infectivity of produced... |
|
|
Conjugated linoleic acid induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation.
J. Inflamm. (Lond.) 12 , 15, (2015) Atherosclerosis, the underlying cause of heart attack and strokes, is a progresive dyslipidemic and inflammatory disease where monocyte-derived macrophage cells play a pivotal role. Although most of the mechanisms that contribute to the progression of atheros... |
|
|
CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.
Mol. Pharmacol. 87(5) , 878-89, (2015) Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporter... |
|
|
Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.
Mol. Pharmacol. 86(5) , 570-9, (2014) The retinoid X receptor (RXR) partners with numerous nuclear receptors, such as the peroxisome proliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR). Although each heterodimer can be activated by specific liga... |
|
|
LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis.
Mol. Cell. Biol. 35(1) , 52-62, (2015) The LIM-only protein FHL2 is expressed in smooth muscle cells (SMCs) and inhibits SMC-rich-lesion formation. To further elucidate the role of FHL2 in SMCs, we compared the transcriptomes of SMCs derived from wild-type (WT) and FHL2 knockout (KO) mice. This re... |
|
|
Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells.
Atherosclerosis 235(2) , 519-25, (2014) ATP-binding cassette transporter A1 (ABCA1) is critical in exporting cholesterol from macrophages and plays a protective role in the development of atherosclerosis. This study was to determine the effects and potential mechanisms of Chlamydia pneumoniae (C. p... |
|
|
RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.
FEBS Lett. 589(4) , 455-60, (2015) Receptor-interacting protein 140 (RIP140) is a multifunctional coregulator of lipid metabolism and inflammation. However, the potential role of RIP140 in atherosclerosis remains unknown. The present study investigated the impact of RIP140 on foam cell formati... |