DC Chemicals Limited
China
Product Name: T0901317
Price: $300.0/100mg $600.0/250mg $1200.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

293754-55-9

293754-55-9 structure

293754-55-9 structure

Name: T0901317
Chemical Name: N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
CAS Number: 293754-55-9
Molecular Formula: C₁₇H₁₂F₉NO₃S
Molecular Weight: 481.333
Catalog: Signaling Pathways Metabolic Enzyme/Protease FXR
Create Date: 2018-12-23 01:14:20
Modify Date: 2024-01-02 15:01:56
T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively.

Name	N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Synonyms	N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]- N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide MFCD03412028 N-[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide T0901317

Description	T0901317 is a potent and selective agonist for LXR and FXR, with EC50s of 50 nM and 5 μM, respectively.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> Metabolic Enzyme/Protease >> LXR Research Areas >> Cancer
References	[1]. Ding H et al. LXR agonist T0901317 upregulates thrombomodulin expression in glomerular endothelial cells by inhibition of nuclear factor?κB. Mol Med Rep. 2016 Jun;13(6):4888-96 [2]. Baranowski M et al. Insulin-sensitizing effect of LXR agonist T0901317 in high-fat fed rats is associated with restored muscle GLUT4 expression and insulin-stimulated AS160 phosphorylation. Cell Physiol Biochem. 2014;33(4):1047-5

Density	1.5±0.1 g/cm3
Boiling Point	470.5±55.0 °C at 760 mmHg
Melting Point	116-122° C
Molecular Formula	C₁₇H₁₂F₉NO₃S
Molecular Weight	481.333
Flash Point	238.4±31.5 °C
Exact Mass	481.039429
PSA	65.99000
LogP	4.82
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.491
Storage condition	-20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport