N-Acetyltryptamine
N-Acetyltryptamine structure
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Common Name | N-Acetyltryptamine | ||
|---|---|---|---|---|
| CAS Number | 1016-47-3 | Molecular Weight | 202.25200 | |
| Density | 1.164 g/cm3 | Boiling Point | 484.7ºC at 760 mmHg | |
| Molecular Formula | C12H14N2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 246.9ºC | |
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Chloroplastic and cytoplasmic overexpression of sheep serotonin N-acetyltransferase in transgenic rice plants is associated with low melatonin production despite high enzyme activity.
J. Pineal Res. 58(4) , 461-9, (2015) Serotonin N-acetyltransferase (SNAT), the penultimate enzyme in melatonin biosynthesis, catalyzes the conversion of serotonin into N-acetylserotonin. Plant SNAT is localized in chloroplasts. To test SNAT localization effects on melatonin synthesis, we generat... |
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Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.
Biochem. Biophys. Res. Commun. 282(5) , 1229-36, (2001) Site-directed mutation of serine 110 (Ser(3.35)) and serine 114 (Ser(3.39)) in the human melatonin MT(1) receptor to alanine residues reduced ligand binding affinities of seven known melatonin receptor agonists and partial agonists by 3- to 15-fold. These mut... |
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[The biosynthesis of low-molecular-weight nitrogen-containing secondary metabolite-alkaloids by the resident strains of Penicillium chrysogenum and Penicillium expansum isolated on the board of the Mir space station ].
Mikrobiologiia 71(6) , 773-7, (2002) The analysis of the absorption spectra of the low-molecular-weight nitrogen-containing secondary metabolites--alkaloids--of 4 Penicillium chrysogenum strains and 6 Penicillium expansum strains isolated on board the Mir space station showed that all these stra... |
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Melatonin receptor pharmacology: toward subtype specificity.
Biol. Cell 89 , 531-537, (1998) The recent cloning of three distinct melatonin receptor subtypes (Mel1a, Mel1b and Mel1c) which are part of a new family of G-protein coupled receptors, and probably mediate the physiological actions of the hormone, has spurred interest in the design of analo... |
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Serotonin metabolism in rat skin: characterization by liquid chromatography-mass spectrometry.
Arch. Biochem. Biophys. 421(1) , 61-6, (2004) We have recently uncovered the full expression of novel cutaneous serotoninergic and melatoninergic systems in the human and hamster skin. In this work, we have characterized serotonin metabolism in the rat skin using liquid chromatography-mass spectrometry a... |
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Diurnal regulation of arylalkylamine N-acetyltransferase activity in chicken retinal cells in vitro: analysis of culture conditions.
Mol. Vis. 9 , 52-9, (2003) Arylalkylamine N-acetyltransferase (AANAT) is a key regulatory enzyme in the synthesis of melatonin, which displays daily fluctuations in chicken retinal photoreceptors in vivo. The purpose of the present study was to determine if cultures of embryonic neural... |
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The electrophysiological effects of melatonin and a putative melatonin antagonist (N-acetyltryptamine) on rat suprachiasmatic neurones in vitro.
Neurosci. Lett. 95(1-3) , 296-301, (1988) Several studies have implicated the suprachiasmatic nuclei (SCN) as a target for the action of melatonin in its regulation of seasonal and circadian behaviour. Single-unit activity from the SCN and adjacent paraventricular area and anterior hypothalamus was r... |
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Rapid and simple measurement of serotonin N-acetyltransferase activity by liquid biphasic diffusion assay.
Neurochem. Int. 35(6) , 447-51, (1999) We report here a rapid, simple, and accurate method to assay for serotonin N-acetyltransferase (NAT) activity. This assay relies on the selective diffusion of radiolabeled acetyltryptamine into a water-immiscible scintillation fluid. Unlike organic solvent ex... |
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Indolyl alkaloid derivatives, Nb-acetyltryptamine and oxaline from a marine-derived fungus.
Arch. Pharm. Res. 26(1) , 21-3, (2003) Indolyl alkaloids, Nb-acetyltryptamine (1) and the known oxaline (2) have been isolated from the organic extract of the broth of an unidentified fungus collected from the surface of the marine red alga Gracilaria verrucosa. The structure of Nb-acetyltryptamin... |
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Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp.
Chem. Biodivers. 8(10) , 1914-20, (2011) Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated fr... |