Chemistry & Biodiversity 2011-10-01

Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp.

Xianwei Zou, Shuchun Liu, Zhihui Zheng, Hua Zhang, Xulin Chen, Xingzhong Liu, Erwei Li

Index: Chem. Biodivers. 8(10) , 1914-20, (2011)

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Abstract

Tricladins A and B (1 and 2, resp.), new imidazolone-containing alkaloids, together with five known metabolites, bacillamides A, B (3 and 4, resp.), 20-hydroxyaflavinine (5), N-(2-phenylethyl)acetamide (6), and N(b)-acetyltryptamine (7), have been isolated from the crude extract of the ascomycete fungus Tricladium sp. The structures of 1 and 2 were elucidated primarily by NMR and MS methods. Compound 2 showed marginal cytotoxicity against MDA-MB-231 human breast cancer cells, whereas the known metabolite 4 displayed an inhibitory effect on HIV-1 replication in C8166 cells.Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich.