(Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt
(Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt structure
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Common Name | (Ala1.3.11.15)-Endothelin-1 trifluoroacetate salt | ||
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| CAS Number | 121204-87-3 | Molecular Weight | 2367.674 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 2391.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C109H163N25O32S | Melting Point | N/A | |
| MSDS | USA | Flash Point | 1400.1±34.3 °C | |
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Alterations in ET-1, not nitric oxide, in 1-week-old lambs with increased pulmonary blood flow.
Am. J. Physiol. Heart Circ. Physiol. 284(2) , H480-90, (2003) Altered pulmonary vascular reactivity is a source of morbidity and mortality for children with congenital heart disease and increased pulmonary blood flow. Nitric oxide (NO) and endothelin (ET)-1 are important mediators of pulmonary vascular reactivity. We hy... |
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Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs.
Pediatr. Res. 40(1) , 152-7, (1996) At birth, pulmonary vasodilation occurs during rhythmic distension of the lungs with oxygen. Both mechanical and humoral factors are involved, including the release of vasoactive substances such as prostacyclin and endothelium-derived nitric oxide (EDNO). How... |
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Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist.
Neuroreport 18(12) , 1275-9, (2007) The role of endothelin (ET)B receptors in chemokine production in the brain of rats was examined. Intracerebroventricular administration of 500 pmol/day of Ala(1,3,11,15)-ET-1, a selective ETB agonist, for 3 or 7 days increased monocyte chemoattractant protei... |
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[Ala1,3,11,15]endothelin-1 analogs with ETB agonistic activity.
Biochem. Biophys. Res. Commun. 179(1) , 286-92, (1991) A linear peptide analog of endothelin (ET)-1, [Ala1,3,11,15]ET-1 (4AlaET-1), and its truncated peptide analogs were synthesized to study the structural requirements of ET-1 for the recognition of ETs-nonselective ETB receptors. ET-1 exhibited sub-nanomolar bi... |
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Endothelin and structurally related analogs distinguish between endothelin receptor subtypes.
Biochem. Biophys. Res. Commun. 183(2) , 566-71, (1992) The endothelin (ET) analog ET-1[1,3,11,15-Ala] was compared with ET-1, ET-2, ET-3 and sarafotoxins (SRTX) S6b and S6c for receptor binding and function. All the peptides exhibited high affinity binding and contracted rabbit pulmonary artery with near equal po... |
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Endothelinb receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension.
J. Cardiovasc. Pharmacol. 25(2) , 207-15, (1995) The hemodynamic effects of endothelin-1 (ET-1) are mediated by at least two distinct receptors: ETa and ETb receptors. Recently, ETb receptor agonists (4 Ala ET-1 and IRL 1620) were developed. To investigate the role of ETb receptor activation on the pulmonar... |
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Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes.
Biochem. Biophys. Res. Commun. 371(4) , 659-63, (2008) The effects of endothelins (ETs) on the production of stromelysins, a sub-family of matrix metalloproteinases, were examined in cultured astrocytes. The treatment of cultured rat astrocytes with ET-1 increased stromelysin-1 mRNA levels, while stromelysin-2 an... |
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Solid-phase synthesis of [Ala1,3,11,15]-endothelin-1 by a modified double-coupling procedure.
Int. J. Pept. Protein Res. 41(5) , 492-8, (1993) [Ala1,3,11,15]-Endothelin-1, a linear analogue of endothelin-1 in which alanines replace the cystine residues, has been prepared by solid-phase synthesis in approximately 17% yield. Fmoc amino acids were coupled using an economical modified double-coupling (s... |
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Endothelin-3 mediated proliferation in wounded human umbilical vein endothelial cells.
Biochem. Biophys. Res. Commun. 196(1) , 369-75, (1993) An in vitro model of endothelial cell injury was used to investigate the role of endothelins and related peptides in endothelial repair. Endothelin-3 (10-100 nM) enhanced wound repair over an 18 h period by promoting proliferation, an effect not inhibited by ... |
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Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ET B receptor agonist.
Neurosci. Lett. 469(3) , 343-7, (2010) Aquaporins (AQPs) comprise a family of water channel proteins, some of which are expressed in brain. Expressions of brain AQPs are altered after brain insults, such as ischemia and head trauma. However, little is known about the regulation of brain AQP expres... |