N-(4-(2-benzimidazolyl)phenyl)maleimide
N-(4-(2-benzimidazolyl)phenyl)maleimide structure
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Common Name | N-(4-(2-benzimidazolyl)phenyl)maleimide | ||
|---|---|---|---|---|
| CAS Number | 27030-97-3 | Molecular Weight | 289.288 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 556.3±52.0 °C at 760 mmHg | |
| Molecular Formula | C17H11N3O2 | Melting Point | 247ºC | |
| MSDS | N/A | Flash Point | 290.3±30.7 °C | |
| Symbol |
GHS03, GHS05, GHS06, GHS08, GHS09 |
Signal Word | Danger | |
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Conformational change accompanying formation of oligomycin-induced Na(+)-bound forms and their conversion to ADP-sensitive phosphoenzymes in Na+,K(+)-ATPase.
J. Biochem. 109(2) , 299-306, (1991) Oligomycin reduced the fluorescence intensity of an N-(p-(2-benzimidazoly)phenyl) maleimide (BIPM) probe at Cys-964 of the alpha-chain of pig kidney Na+,K(+)-ATPase with increase in the concentration of Na+ with a Hill coefficient of nh = 0.77 with Kh = 231 m... |
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Different susceptibility to phospholipase A2 treatment of the fluorescence intensity changes in the vicinity of Cys-964 and Lys-501 in the alpha-chain of probe-labeled Na+,K(+)-ATPase.
J. Biochem. 115(3) , 454-62, (1994) Phospholipase A2 [EC 3.1.1.4] treatment of pig kidney Na+,K(+)-ATPase [EC 3.6.1.3] labeled with fluorescence probes at the alpha-chain reduced the extent of the fluorescence intensity change of an N-[p-(2-benzimidazolyl)phenyl]maleimide (BIPM) probe at Cys-96... |
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ATP-induced dynamic fluorescence changes of a N-[p-(2-benzimidazolyl)phenyl]maleimide probe at Cys241 in the alpha-chain of pig stomach H+,K+-ATPase.
J. Biochem. 122(3) , 659-65, (1997) H+,K+-ATPase preparations from pig stomach were modified with a sulfhydryl fluorescence reagent, N-[p-(2-benzimidazolyl)phenyl] maleimide (BIPM). The addition of ATP to the modified enzyme preparations in the presence of Mg2+ decreased the BIPM fluorescence b... |
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[Ouabain binding and the conformational change in Na+, K+ -ATPase].
Nippon. Yakurigaku Zasshi. 86(3) , 181-8, (1985) The addition of ouabain to the Na+, K+-ATPase [EC.3.6.1.3] of pig kidney modified with N-[p-(2-benzimidazolyl) phenyl] maleimide gradually increased the fluorescence and the amount of phosphoenzyme from Pi with the same time course in the presence of 0.43 mM ... |
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Organic fluorescence reagents in the study of enzymes and proteins.
Angew. Chem. Int. Ed. Engl. 16 , 137, (1977)
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Fluorescent thiol reagents. V. Microfluorometry of thiol compounds with a fluorescent-labeled maleimide.
Anal. Biochem. 48 , 557, (1972)
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Stopped-flow kinetic investigations of conformational changes of pig kidney Na+,K+-ATPase.
Biochemistry 36 , 13406, (1997) The kinetics of Na+-dependent partial reactions of the Na+,K+-ATPase were investigated via the stopped-flow technique using the fluorescent labels RH421 and BIPM. After the enzyme is mixed with MgATP, both labels give almost identical kinetic responses. Under... |
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Escherichia coli B gamma-glutamylcysteine synthetase: modification, purification, crystallization and preliminary crystallographic analysis.
Acta Crystallogr. D Biol. Crystallogr. 58(Pt 2) , 316-8, (2002) Escherichia coli B gamma-glutamylcysteine synthetase (gammaGCS) catalyzes the ATP-dependent coupling of L-Glu and L-Cys to form the glutathione precursor gamma-L-Glu-Cys and is a target for development of potential therapeutic agents. By introducing four poin... |
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Structural changes in Na, K-ATPase estimated by intrinsic and extrinsic fluorescence probes.
Prog. Clin. Biol. Res. 268A , 369-76, (1988)
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Reversible changes in the fluorescence energy transfer accompanying formation of reaction intermediates in probe-labeled (Na+,K+)-ATPase.
J. Biol. Chem. 268(21) , 15588-94, (1993) A preparation of pig kidney Na+,K(+)-ATPase showed changes in fluorescence energy transfer between probes bound to the alpha-subunit. Excitation (305 nm) of an N-(p-(2-benzimidazolyl)phenyl)maleimide (BIPM) probe, which was covalently bound to Cys-964, and ex... |