Squaric acid
Squaric acid structure
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Common Name | Squaric acid | ||
|---|---|---|---|---|
| CAS Number | 2892-51-5 | Molecular Weight | 114.056 | |
| Density | 2.4±0.1 g/cm3 | Boiling Point | 251.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C4H2O4 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 119.8±26.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers.
Toxicol. Appl. Pharmacol. 289 , 177-84, (2015) Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological ... |
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Chiral squaramide derivatives are excellent hydrogen bond donor catalysts.
J. Am. Chem. Soc. 130(44) , 14416-7, (2008) Thioureas represent the dominant platform for hydrogen bond promoted asymmetric catalysts. A large number of reactions, reported in scores of publications, have been successfully promoted by chiral thioureas. The present paper reports the use of squaramides a... |
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Strategies for optimizing the performance of carbazole thiophene appended unsymmetrical squaraine dyes for dye-sensitized solar cells.
Phys. Chem. Chem. Phys. 17 , 23095-103, (2015) Unsymmetrical squaraine dyes (CTSQ-1 and CTSQ-2) with carbazole thiophene donor units were synthesized, characterized and used as sensitizers in dye-sensitized solar cells (DSSCs). These squaraines exhibited intense absorption in the near IR-visible region of... |
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An application of polymer-enhanced capillary transient isotachophoresis with an emissive boronic acid functionalized squarylium dye as an on-capillary labeling agent for gram-positive bacteria.
Anal. Sci. 29(1) , 157-9, (2013) In this paper, the characterization and application of the "PectI" (polymer-enhanced capillary transient isotachophoresis) technique for the separation and detection of same genus, gram-positive bacteria, Bacillus globigii (Bg) and Bacillus subtilis, is demon... |
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The complexation of a novel squaric bis(thiosemicarbazone); 3,4-bis{[(aminothioxomethyl)amino]azamethylene}cyclobut-ene-1,2-diol.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 78(3) , 1097-104, (2011) A novel chelating agent (Sqtsc; H(4)L) bearing both hard and soft donor atoms was synthesized by the condensation of squaric acid with thiosemicarbazide. The ligand has two symmetrical sets of donor atoms (SNO), therefore, it was allowed to react with the met... |
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The binding site of zinc and indium metal to amino acid derivatized squarate complexes - Implications in inhibitor and mediator designs.
Bioorg. Chem. 38(5) , 234-41, (2010) Three novel metal squaric acid-peptide complexes, SQI-SQIII were prepared by addition of indium triflate or zinc chloride to the previously reported compounds [1], 3-(hydroxymethylamino)-4-(l-isoleucine methyl ester)-3-cyclobutene-1,2-dione (squarate 1), and ... |
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Evaluation of the inhibitory potential of five squaric acid derivatives against pancreatic lipase.
J. Enzyme Inhib. Med. Chem. 26(4) , 587-91, (2011) A series of 4-alkylamino-2-ethoxycyclobut-3en-1,2-diones has been synthesized, characterized and their inhibitory effect on pancreatic lipase (PL) was evaluated. The compound 1 has shown relatively high potency (IC(50) = 0.11 mM) compared with the most effect... |
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Structural and spectroscopic elucidation of tetrapetide glycyl-(L)-prolyl-glycyl-glycine and its hydrogensquarate.
Protein Pept. Lett. 15(7) , 713-8, (2008) The IR-spectroscopic and structural elucidation of tetrapeptide glycyl-(L)-prolyl-glycyl-glycine and its hydrogensquarate was performed by employing linear-polarized IR-spectroscopy of oriented colloid suspensions in nematic host as well as mass spectrometry.... |
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Squaramide-tertiary amine catalyzed asymmetric cascade sulfa-Michael/Michael addition via dynamic kinetic resolution: access to highly functionalized chromans with three contiguous stereocenters.
Org. Lett. 15(6) , 1190-3, (2013) An efficient asymmetric cascade sulfa-Michael/Michael addition reaction catalyzed by a chiral bifunctional squaramide-tertiary amine catalyst has been developed. This organocatalytic cascade reaction provides easy access to highly functionalized chromans with... |
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Squaramide-based reagent for selective chromogenic sensing of Cu(II) through a zwitterion radical.
Org. Lett. 12(17) , 3840-3, (2010) A minimalist squaramide-based chemodosimeter for Cu(2+) is described. Upon selective chelation to 2, Cu(2+) induces the formation of a highly colored zwitterionic radical, which is kinetically stable for hours. The presence of a radical is confirmed by EPR an... |