Flutamide
Flutamide structure
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Common Name | Flutamide | ||
|---|---|---|---|---|
| CAS Number | 13311-84-7 | Molecular Weight | 276.212 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 400.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C11H11F3N2O3 | Melting Point | 112 °C | |
| MSDS | Chinese USA | Flash Point | 195.9±28.7 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Evolutionary history and functional characterization of androgen receptor genes in jawed vertebrates.
Endocrinology 150 , 5415-27, (2009) Vertebrates show diverse sexual characters in sexually attractive and reproductive organs, which are regulated by steroid hormones, particularly androgens. However, the evolutionary history of androgen receptor (AR) gene remains largely unknown on the basis o... |
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Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.
Toxicol. Sci. 141(1) , 78-89, (2014) In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenici... |
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Inhibition of SGK1 enhances mAR-induced apoptosis in MCF-7 breast cancer cells.
Cancer Biol. Ther. 16(1) , 52-9, (2015) Functional membrane androgen receptors (mAR) have previously been described in MCF-7 breast cancer cells. Their stimulation by specific testosterone albumin conjugates (TAC) activate rapidly non-genomic FAK/PI3K/Rac1/Cdc42 signaling, trigger actin reorganizat... |
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Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish.
Proc. Natl. Acad. Sci. U. S. A. 112(5) , 1475-80, (2015) Bisphenol A (BPA), a ubiquitous endocrine disruptor that is present in many household products, has been linked to obesity, cancer, and, most relevant here, childhood neurological disorders such as anxiety and hyperactivity. However, how BPA exposure translat... |
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Screening of bisphenol A, triclosan and paraben analogues as modulators of the glucocorticoid and androgen receptor activities.
Toxicol. In Vitro 29(1) , 8-15, (2014) A homeostasis of the glucocorticoid and androgen endocrine system is essential to human health. Their disturbance can lead to various diseases, for example cardiovascular, inflammatory and autoimmune diseases, infertility, cancer. Fifteen widely used industri... |
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Influence of Testosterone on Inflammatory Response in Testicular Cells and Expression of Transcription Factor Foxp3 in T Cells.
Am. J. Reprod. Immunol. 74 , 12-25, (2015) Previous studies demonstrated a strong association between low androgen levels and reduced capacity to mount an inflammatory response. However, the mechanisms underlying these observations are largely not understood.Generation of CD4+CD25+Foxp3+ regulatory T ... |
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Aromatase (Cyp19a1b) in the pituitary is dynamically involved in the upregulation of lhb but not fshb in the vitellogenic female ricefield eel Monopterus albus.
Endocrinology 155(11) , 4531-41, (2014) Aromatase, encoded by Cyp19a1, is expressed in the pituitary of vertebrates; however, its physiological relevance remains poorly defined. In teleosts, the duplicated cyp19a1b is preferentially expressed in the pituitary where LH and FSH are synthesized in dis... |
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Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.
Mol. Cancer Ther. 14 , 713-26, (2015) Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development of incurable castrate-resistant prostate cancer. However, therapies targeting the AR signal... |
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Effects of the anti-androgen cyproterone acetate (CPA) on oocyte meiotic maturation in rainbow trout (Oncorhynchus mykiss).
Aquat. Toxicol. 164 , 34-42, (2015) In the present study, we aimed at characterizing the effect of cyproterone acetate (CPA), an anti-androgenic compound, on oocyte meiotic maturation in a freshwater teleost fish species, the rainbow trout (Oncorhynchus mykiss). Fully-grown post-vitellogenic ov... |
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Anogenital distance plasticity in adulthood: implications for its use as a biomarker of fetal androgen action.
Endocrinology 156(1) , 24-31, (2015) Androgen action during the fetal masculinization programming window (MPW) determines the maximum potential for growth of androgen-dependent organs (eg, seminal vesicles, prostate, penis, and perineum) and is reflected in anogenital distance (AGD). As such, de... |