Itopride hydrochloride
Itopride hydrochloride structure
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Common Name | Itopride hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 122892-31-3 | Molecular Weight | 394.892 | |
| Density | N/A | Boiling Point | 510.1ºC at 760 mmHg | |
| Molecular Formula | C20H27ClN2O4 | Melting Point | 194-1950ºC | |
| MSDS | Chinese USA | Flash Point | 262.3ºC | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase.
Toxicol. Lett. 232(3) , 557-65, (2015) Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Oximes have been widely recognized for their potency to reactivate the inhibited enzyme. The limited ... |
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QbD-enabled systematic development of gastroretentive multiple-unit microballoons of itopride hydrochloride.
Drug Deliv. 23 , 437-51, (2016) The objectives of present studies were to develop the systematically optimized multiple-unit gastroretentive microballoons, i.e. hollow microspheres of itopride hydrochloride (ITH) employing quality by design (QbD)-based approach. Initially, the patient-centr... |
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[Effect of HSR-803 on gastrointestinal motility].
Nihon Heikatsukin Gakkai Zasshi 25(6) , 313-5, (1989)
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A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine.
Gastroenterology 99(2) , 401-8, (1990) A novel water-soluble dopamine-2 antagonist, N-[4-[2-(dimethylamino) ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) was synthesized and assayed for its gastrointestinal smooth muscle stimulating activity in vivo and in vitro. In the in vivo stu... |
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Stimulatory effect of N-[4-[2-(dimethylamino)-ethoxy] benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) on normal and delayed gastrointestinal propulsion.
Jpn. J. Pharmacol. 56(3) , 261-9, (1991) To estimate the effect of a new gastroprokinetic agent, N-[4-[2-(dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803), on non-ulcer dyspepsia, the influence of HSR-803 on gastrointestinal propulsion was assayed in dogs, rats and mice in... |
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Inhibitory effects of KW-5092, a novel gastroprokinetic agent, on the activity of acetylcholinesterase in guinea pig ileum.
Jpn. J. Pharmacol. 66(4) , 397-403, (1994) KW-5092 ([1-[2-[[[5-(piperidinomethyl)-2- furanyl]methyl]amino]ethyl]-2-imidazolidinylidene] propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase (AChE) inhibitory activity and acetylcholine release facilitatory activity. The... |
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Simultaneous determination of a new gastrointestinal prokinetic agent (HSR-803) and its metabolites in human serum and urine by high-performance liquid chromatography using automated column-switching.
J. Chromatogr. A. 576(1) , 174-8, (1992) A method based on high-performance liquid chromatography using column-switching is described for the simultaneous determination of HSR-803 and its metabolites in human serum and urine. The system uses a six-port valve with a Nucleosil CN pre-column for on-lin... |
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Stimulatory effects of HSR-803 on ileal motor activity.
Jpn. J. Pharmacol. 62(4) , 395-401, (1993) Stimulatory effects of HSR-803 on intestinal motor activity in vitro were studied in guinea pig ileum. HSR-803 (1 x 10(-6)-1 x 10(-4) M) increased the amplitude of longitudinal muscle contractions and increased the frequency of peristalsis in isolated segment... |