Clozapine
Clozapine structure
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Common Name | Clozapine | ||
|---|---|---|---|---|
| CAS Number | 5786-21-0 | Molecular Weight | 326.823 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 489.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C18H19ClN4 | Melting Point | 182-185°C | |
| MSDS | Chinese USA | Flash Point | 249.6±31.5 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.
J. Pharmacol. Toxicol. Methods 76 , 83-95, (2015) Glutathione (GSH) trapping assays are widely used to predict the post-marketing risk for idiosyncratic drug reactions (IDRs) in the pharmaceutical industry. Although several GSH derivatives have been introduced as trapping reagents for reactive intermediates,... |
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Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Biochem. Pharmacol. 95 , 311-23, (2015) Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behavior, but little is known on whether this receptor can be targeted by neuropsychopharmacological a... |
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Imaging MALDI MS of Dosed Brain Tissues Utilizing an Alternative Analyte Pre-extraction Approach.
J. Am. Soc. Mass Spectrom. 26 , 967-73, (2015) Matrix-assisted laser desorption ionization (MALDI) imaging mass spectrometry has been adopted in the pharmaceutical industry as a useful tool to detect xenobiotic distribution within tissues. A unique sample preparation approach for MALDI imaging has been de... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Effects of a glycine transporter-1 inhibitor and D-serine on MK-801-induced immobility in the forced swimming test in rats.
Behav. Brain Res. 278 , 186-92, (2015) Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic a... |
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Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro.
PLoS ONE 10 , e0141829, (2015) First- and second-generation antipsychotics (FGAs and SGAs, respectively), both inhibit cholesterol biosynthesis and impair the intracellular cholesterol trafficking, leading to lipid accumulation in the late endosome/lysosome compartment. In this study we ex... |
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Formulation and evaluation of clozapine orally disintegrating tablets prepared by direct compression.
Pharmazie 68(2) , 110-6, (2013) Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC formatio... |
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Analysis of drugs in plasma samples from schizophrenic patients by column-switching liquid chromatography-tandem mass spectrometry with organic-inorganic hybrid cyanopropyl monolithic column.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 993-994 , 26-35, (2015) This study reports on the development of a rapid, selective, and sensitive column-switching liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to analyze sixteen drugs (antidepressants, anticonvulsants, anxiolytics, and antipsychotics) in plasma... |
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Clozapine promotes the proliferation of granulocyte progenitors in the bone marrow leading to increased granulopoiesis and neutrophilia in rats.
Chem. Res. Toxicol. 27(7) , 1109-19, (2014) Clozapine is an atypical antipsychotic that is limited in its use due to the risk of idiosyncratic agranulocytosis. The bone marrow is suspected to be the site of the reaction, and indirect measurements in patients suggest that neutrophil production and matur... |
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Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis.
Chem. Res. Toxicol. 27(7) , 1104-8, (2014) Clozapine is effective in the treatment of schizophrenia; however, its use is limited by a relatively high incidence of idiosyncratic agranulocytosis. The mechanism of clozapine-induced idiosyncratic agranulocytosis is unknown. Although most patients treated ... |