Difluoxacin hydrochloride
Difluoxacin hydrochloride structure
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Common Name | Difluoxacin hydrochloride | ||
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| CAS Number | 91296-86-5 | Molecular Weight | 435.852 | |
| Density | 1.409 g/cm3 | Boiling Point | 595.5ºC at 760 mmHg | |
| Molecular Formula | C21H20ClF2N3O3 | Melting Point | >245ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 313.9ºC | |
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Determination of fluoroquinolones in chicken feces - a new liquid-liquid extraction method combined with LC-MS/MS.
Environ. Toxicol. Pharmacol. 38(3) , 792-9, (2014) The application of antibiotics including fluoroquinolones to farming animals is widespread and may lead to the development of antibiotic resistance and other environmental effects. To calculate environmental loads and for a proper risk assessment it is necess... |
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Occurrence and distribution of antibiotics in urban soil in Beijing and Shanghai, China.
Environ. Sci. Pollut. Res. Int. 22 , 11360-71, (2015) The recycling of reclaimed wastewater for irrigation and road cleaning is an important strategy to minimize water scarcity in megacities. However, little is known regarding the potential accumulation of antibiotics contained in reclaimed wastewater in urban s... |
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Facile synthesis of polyaniline-coated SiO₂ nanofiber and its application in enrichment of fluoroquinolones from honey samples.
Talanta 140 , 29-35, (2015) In this study, polyaniline coated SiO2 nanofibers (PANI/SiO2) was prepared by combining electrospinning technique with in-situ polymerization. The proposed strategy for the preparation of PANI/SiO2 can eliminate the aggregation of PANI and the yield of PANI/S... |
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Determination of selected veterinary antimicrobials in poultry excreta by UHPLC-MS/MS, for application in Salmonella control programs.
Anal. Bioanal. Chem 407 , 4447-57, (2015) The most important source of Salmonella spp. infection in humans is by the consumption of contaminated poultry products. Due to the risk of resistance development and its transfer from animals to humans, the Belgian Royal Decree concerning the eradication of ... |
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Validation of a streamlined multiclass, multiresidue method for determination of veterinary drug residues in bovine muscle by liquid chromatography-tandem mass spectrometry.
Anal. Bioanal. Chem 407 , 4423-35, (2015) Multiclass, multiresidue methods are becoming increasingly popular in regulatory monitoring programs due to their increased analytical scope and laboratory efficiency. In this work, we report the development and validation of a new high-throughput analytical ... |
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Determination of water content by capillary gas chromatography coupled with thermal conductivity detection.
Pharmeur. Bio Sci. Notes 2011(2) , 40-4, (2011) This article presents some experience obtained by applying capillary gas chromatography coupled with thermal conductivity detection (GC/TCD) to the determination of water in substances for pharmaceutical use. This technique represents a useful, orthogonal too... |
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Quantification of danofloxacin and difloxacin in chicken tissues in the presence of sarafloxacin as interference.
J. Agric. Food Chem. 57(17) , 7627-33, (2009) A new spectrofluorimetric method has been developed for the quantification of danofloxacin (DANO) and difloxacin (DIFLO), in the presence of the primary metabolite of difloxacin, with sarafloxacin (SARA) as interference, in chicken tissue samples. The method ... |
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Simultaneous determination of quinolones for veterinary use by high-performance liquid chromatography with electrochemical detection.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(3-4) , 398-402, (2010) A selective method based on high-performance liquid chromatography with electrochemical detection (HPLC-ECD) has been developed to enable simultaneous determination of three fluoroquinolones (FQs), namely danofloxacin (DANO), difloxacin (DIFLO) and sarafloxac... |
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Disposition kinetics and pharmacokinetics--pharmacodynamic integration of difloxacin against Staphylococcus aureus isolates from rabbits.
Res. Vet. Sci. 84(1) , 90-4, (2008) The pharmacokinetics of difloxacin were studied following intravenous (IV), subcutaneous (SC) and oral administration of 5mg/kg to healthy white New Zealand rabbits (n = 6). Difloxacin concentrations were determined by HPLC assay with fluorescence detection. ... |
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Plasma disposition and tissue depletion of difloxacin and its metabolite sarafloxacin in the food producing animals, chickens for fattening.
Food Chem. Toxicol. 49(2) , 441-9, (2011) Chickens were used to investigate plasma disposition of difloxacin after single intravenous (IV) and oral dose (10 mg/kg body weight (BW)) and to study residue depletion of difloxacin and its major metabolite sarafloxacin after multiple oral doses (10 mg difl... |