tubulin polymerization inhibitor
tubulin polymerization inhibitor structure
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Common Name | tubulin polymerization inhibitor | ||
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| CAS Number | 564468-51-5 | Molecular Weight | 328.361 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 524.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C22H16O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 188.8±23.6 °C | |
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Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes.
Biomater. Sci. 3 , 1114-23, (2015) In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of cholesterol modification on siRNA delivery was investigated. PAMD-Ch/siRNA polyplexe... |
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Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Exp. Hematol. 43 , 393-403.e2, (2015) Thioredoxin-interacting protein (TXNIP) is involved in various cellular processes including redox control, metabolism, differentiation, growth, and apoptosis. With respect to hematopoiesis, TXNIP has been shown to play roles in natural killer cells, dendritic... |
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Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.
J. Virol. 89 , 9841-52, (2015) It has recently been proposed that the herpes simplex virus (HSV) protein ICP0 has cytoplasmic roles in blocking antiviral signaling and in promoting viral replication in addition to its well-known proteasome-dependent functions in the nucleus. However, the m... |
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Genetic manipulation of RPS5 gene expression modulates the initiation of commitment of MEL cells to erythroid maturation: Implications in understanding ribosomopathies.
Int. J. Oncol. 47 , 303-14, (2015) Impairment of ribosome biogenesis contributes to the molecular pathophysiology of ribosomopathies by deregulating cell-lineage specific proliferation, differentiation and apoptosis decisions of haematopoietic progenitor cells. Here, using pro-erythroblast-lik... |
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Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repression.
Nucleic Acids Res. 42(14) , 8954-69, (2014) Hypoxia is associated with a variety of physiological and pathological conditions and elicits specific transcriptional responses. The elongation competence of RNA Polymerase II is regulated by the positive transcription elongation factor b (P-TEFb)-dependent ... |
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Regulatory role of nucleophosmin during the differentiation of human liver cancer cells.
Int. J. Oncol. 45(1) , 264-72, (2014) Nucleophosmin (NPM, also known as B23), mainly localized in the nucleolus, has been reported to be overexpressed in many types of human cancer, including colon, ovarian, prostate and gastric cancer. NPM was identified while screening the differential nuclear ... |
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Polymeric Plerixafor: effect of PEGylation on CXCR4 antagonism, cancer cell invasion, and DNA transfection.
Pharm. Res. 31(12) , 3538-48, (2014) To determine the effect of PEG modification on pharmacologic and gene delivery properties of polymeric CXCR4 antagonist based on Plerixafor.Polymeric Plerixafor (PAMD) was synthesized from Plerixafor (AMD3100) and grafted with different amounts of PEG (2 kDa)... |