564468-51-5

564468-51-5 structure

Name: tubulin polymerization inhibitor
Chemical Name: 10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone
CAS Number: 564468-51-5
Molecular Formula: C₂₂H₁₆O₃
Molecular Weight: 328.361
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-08 05:06:12
Modify Date: 2025-08-25 16:08:57
Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].

Name	10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone
Synonyms	9(10H)-Anthracenone, 10-[(3-hydroxy-4-methoxyphenyl)methylene]- 10-(3-Hydroxy-4-methoxybenzylidene)-9(10H)-anthracenone 10-(3-hydroxy-4-methoxybenzylidene)anthracen-9(10H)-one

Description	Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
In Vitro	Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner[1]. Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM[1]. Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM[1]. Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway[1].
References	[1]. Chatterji BP, et al. HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin. Biochem Pharmacol. 2010 Jul 1;80(1):50-61.

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