Ganirelix Acetate

Ganirelix Acetate Structure
Ganirelix Acetate structure
Common Name Ganirelix Acetate
CAS Number 129311-55-3 Molecular Weight 1690.423
Density N/A Boiling Point N/A
Molecular Formula C84H121ClN18O17 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors.

Am. J. Physiol. Endocrinol. Metab. 305(7) , E818-25, (2013)

Hyperandrogenism and vascular dysfunction often coexist in women with polycystic ovary syndrome (PCOS). We hypothesized that testosterone compromises cutaneous microvascular dilation in women with PCOS via the endothelin-1 ET-B subtype receptor. To control an...

GnRH antagonist versus long GnRH agonist protocol in poor IVF responders: a randomized clinical trial.

Eur. J. Obstet. Gynecol. Reprod. Biol. 166(1) , 43-6, (2013)

To compare the efficacy of the long GnRH agonist and the fixed GnRH antagonist protocols in IVF poor responders.This was a randomized controlled trial performed in the Iakentro IVF centre, Thessaloniki, from January 2007 to December 2011, concerning women cha...

Outpatient management of severe early OHSS by administration of GnRH antagonist in the luteal phase: an observational cohort study.

Reprod. Biol. Endocrinol. 10 , 69, (2012)

Management of established severe OHSS requires prolonged hospitalization, occasionally in intensive care units, accompanied by multiple ascites punctures, correction of intravascular fluid volume and electrolyte imbalance. The aim of the present study was to ...

Short-term administration of progesterone and estradiol independently alter carotid-vasomotor, but not carotid-cardiac, baroreflex function in young women.

Am. J. Physiol. Heart Circ. Physiol. 305(7) , H1041-9, (2013)

The individual effects of estrogen and progesterone on baroreflex function remain poorly understood. We sought to determine how estradiol (E2) and progesterone (P4) independently alter the carotid-cardiac and carotid-vasomotor baroreflexes in young women by u...

Replacing GnRH agonists with GnRH antagonists in oocyte recipient cycle did not adversely affect the pregnancy rates

Eur. J. Obstet. Gynecol. Reprod. Biol. 159(2) , 355-8, (2011)

The synchronization of the donor stimulation with the endometrial preparation of the recipient is usually done by downregulating the recipient's pituitary with a GnRH analog.

Analysis of the impact of intravenous LH pulses versus continuous LH infusion on testosterone secretion during GnRH-receptor blockade.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 303(10) , R994-R1002, (2012)

Gonadotrophin-releasing hormone (GnRH) pulsatility is required for optimal luteinizing hormone (LH) secretion, but whether LH pulsatility is required for physiological testosterone (T) secretion is not known. To test the postulate that pulses of recombinant h...

Ovarian stimulation in women with high and normal body mass index: GnRH agonist versus GnRH antagonist.

Gynecol. Endocrinol. 28(10) , 792-5, (2012)

In modern society, obesity has become a major health problem and has been associated with impaired fertility. The aim of this study is to assess the role of obesity in women undergoing controlled ovarian hyperstimulation (COH) stimulated either with GnRH agon...

In vitro fertilization stimulation protocol for normal responder patients.

Gynecol. Endocrinol. 29(2) , 109-12, (2013)

The aim of this prospective observational study is to determine the different outcomes of IVF/ICSI treatments after using antagonists or agonists of gonadotrophin-releasing hormone (GnRH) for controlled ovarian hyperstimulation (COH) in normal responder patie...

A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates.

Gynecol. Endocrinol. 28(10) , 800-4, (2012)

Gonadotropin-releasing hormone (GnRH) antagonists for controlled ovarian stimulation (COS) were only recently introduced into China. The efficacy and safety of the GnRH antagonist ganirelix was assessed in a multicenter, controlled, open-label study, in which...

Evidence that the main adverse effect of ganirelix on pregnancy and implantation rates is on the embryo rather than the endometrium.

Clin. Exp. Obstet. Gynecol. 38(4) , 326-7, (2011)

To compare pregnancy rates following the transfer of thawed frozen embryos according to the type of GnRH antagonist or agonist used during controlled ovarian hyperstimulation (COH).Retrospective review of frozen embryo transfers according to whether a GnRH ag...