l-homocysteinesulfinic acid
l-homocysteinesulfinic acid structure
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Common Name | l-homocysteinesulfinic acid | ||
|---|---|---|---|---|
| CAS Number | 2686-70-6 | Molecular Weight | 331.363 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 523.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H21NO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 270.6±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Behav. Brain Res. 225(2) , 491-7, (2011) For patients with acute lymphoblastic leukemia or non-Hodgkin lymphoma, intrathecal (IT) methotrexate (MTX) significantly reduces the risk of relapse within the central nervous system, but is associated with neurotoxic sequelae. We established a rat model of ... |
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L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.
J. Pharmacol. Exp. Ther. 305 , 131-143, (2003) Moderate hyperhomocysteinemia is associated with several diseases, including coronary artery disease, stroke, Alzheimer's disease, schizophrenia, and spina bifida. However, the mechanisms for their pathogenesis are unknown but could involve the interaction of... |
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Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines.
Neuropharmacology 37 , 277-287, (1998) Comparison of the pharmacological effects of a range of sulphur-containing amino acids on human mGluR1alpha and mGluR5a has been undertaken. cDNAs of each mGluR were transfected into a Syrian hamster tumour cell line AV12-664 that was previously transfected w... |
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Sulphur-containing excitatory amino acid-evoked Ca(2+)-independent release of D-[3H]aspartate from cultured cerebellar granule cells: the role of glutamate receptor activation coupled to reversal of the acidic amino acid plasma membrane carrier.
Neuroscience 50(1) , 107-15, (1992) Sulphur-containing excitatory amino acid transmitter candidates (500 microM) stimulated the Ca(2+)-independent efflux of exogenously-supplied D-[3H]aspartate from primary cultures of cerebellar granule cells superfused continuously with HEPES-buffered saline ... |
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Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors.
Neuroscience 59(2) , 299-308, (1994) The stimulatory effect of excitatory sulphur-containing amino acids on inositol phosphate formation was investigated in primary cultures of cerebellar granule cells. L-Cysteine sulphinate (CSA), L-cysteate (CA), L-homocysteine sulphinate (HCSA), L-homocysteat... |
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The actions of a range of excitatory amino acids at (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-depolarizing receptors on neonatal rat motoneurones.
Neuropharmacology 34(8) , 857-63, (1995) Depolarizations induced by a range of amino acids including some sulphur-containing excitatory transmitter candidates were evoked from motoneurones in the neonatal rat spinal cord under conditions that precluded activation of known ionotropic glutamate recept... |
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L-homocysteine sulfinic acid and L-homocysteic acid stimulate phosphoinositide hydrolysis in rat cortical neurons.
Ann. N. Y. Acad. Sci. 1003 , 461-3, (2003)
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Effect of sulphur containing amino acids on [3H]-acetylcholine release from amacrine cells of the rabbit retina.
Br. J. Pharmacol. 105(3) , 563-8, (1992) 1. The effects of the sulphur containing amino acids, homocysteic acid, homocysteine sulphinic acid, cysteic acid and cysteine sulphinic acid on the release of [3H]-acetylcholine ([3H]-ACh) from the cholinergic amacrine cells of the rabbit retina were examine... |
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Measurement of excitatory sulfur amino acids, cysteine sulfinic acid, cysteic acid, homocysteine sulfinic acid, and homocysteic acid in serum by stable isotope dilution gas chromatography-mass spectrometry and selected ion monitoring.
Anal. Biochem. 220(2) , 249-56, (1994) Oxidized sulfur-containing amino acids are recognized as agonists of excitatory amino acid receptors in the mammalian nervous system. Homologues of glutamic acid (homocysteine sulfinic acid and homocysteic acid) and aspartic acid (cysteine sulfinic acid and c... |
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Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate.
Int. J. Clin. Pharmacol. Ther. 45(9) , 504-15, (2007) Interference of methotrexate (MTX) with the metabolism of homocysteine may contribute to MTX neurotoxicity. In this pilot study we measured the concentration of homocysteine and related metabolites in the cerebrospinal fluid (CSF) of patients with primary cen... |