Tiratricol
Tiratricol structure
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Common Name | Tiratricol | ||
|---|---|---|---|---|
| CAS Number | 51-24-1 | Molecular Weight | 621.932 | |
| Density | 2.5±0.1 g/cm3 | Boiling Point | 531.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C14H9I3O4 | Melting Point | 181.5ºC | |
| MSDS | Chinese USA | Flash Point | 275.3±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc. Natl. Acad. Sci. U. S. A. 104 , 16074-9, (2007) Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might over... |
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Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.
J. Med. Chem. 54 , 8563-73, (2011) The androgen receptor (AR) is the best studied drug target for the treatment of prostate cancer. While there are a number of drugs that target the AR, they all work through the same mechanism of action and are prone to the development of drug resistance. Ther... |
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Pentane-1,5-diol as a percutaneous absorption enhancer.
Arch. Dermatol. Res. 297(6) , 261-5, (2005) Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. Howeve... |
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C-fin: a cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals.
Environ. Toxicol. Chem. 29(2) , 380-8, (2010) There is a need for the development of a rapid method for identifying chemicals that disrupt thyroid hormone (TH) action while maintaining complex tissue structure and biological variation. Moreover, no assay to date allows a simultaneous screen of an individ... |
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Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors.
J. Appl. Toxicol. 33(9) , 991-1000, (2013) Thyroid hormones are essential for the regulation of a wide range of biological processes associated with normal development and metabolism in vertebrates. For the screening of chemicals with a potential thyroid hormone and anti-thyroid hormone activities, we... |
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Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.
J. Med. Chem. 51 , 7075-93, (2008) Phosphonic acid (PA) thyroid hormone receptor (TR) agonists were synthesized to exploit the poor distribution of PA-based drugs to extrahepatic tissues and thereby to improve the therapeutic index. Nine PAs showed excellent TR binding affinities (TRbeta(1), K... |
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QSAR study of selective ligands for the thyroid hormone receptor beta.
Bioorg. Med. Chem. 15 , 5251-61, (2007) In this paper, an accurate and reliable QSAR model of 87 selective ligands for the thyroid hormone receptor beta 1 (TRbeta1) was developed, based on theoretical molecular descriptors to predict the binding affinity of compounds with receptor. The structural c... |
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A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.
PLoS ONE 5 , e9797, (2010) Nuclear receptors (NRs) belong to a superfamily of transcription factors that regulate numerous homeostatic, metabolic and reproductive processes. Taken together with their modulation by small lipophilic molecules, they also represent an important and success... |
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Protective effect of 3,5,3'-triiodothyroacetic and 3,5,3',5'-tetraiodothyroacetic acids on serum albumin fibrillation.
Eur. Biophys. J. 38(7) , 857-63, (2009) Inhibition or reversion of protein self-aggregation has been suggested as a possible preventive mechanism against amyloid diseases, and many efforts are underway to found out molecules capable to restrain the protein aggregation process. In this paper, the in... |