(2,5-Dioxotetrahydro-3-furanyl)acetic acid
(2,5-Dioxotetrahydro-3-furanyl)acetic acid structure
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Common Name | (2,5-Dioxotetrahydro-3-furanyl)acetic acid | ||
|---|---|---|---|---|
| CAS Number | 6318-55-4 | Molecular Weight | 158.109 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 439.9±18.0 °C at 760 mmHg | |
| Molecular Formula | C6H4O5 | Melting Point | 75-78 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 194.6±14.7 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Enhanced shRNA delivery and ABCG2 silencing by charge-reversible layered nanocarriers.
Small 11(8) , 952-62, (2015) Polycationic vectors have been used to deliver short hairpin RNAs (shRNAs) to knock-down genes for cancer therapies, but their inefficiency in lysosomal escape and shRNA release causes their low gene transcription efficiency. Herein, a three-layered polyethyl... |
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Development of biodegradable polymeric implants of RGD-modified PEG-PAMAM-DOX conjugates for long-term intratumoral release.
Drug Deliv. 22 , 389-99, (2015) The sustained release implants can be directly implanted in tumor site by surgery and are promising for cancer treatment.RGD-modified PEGylated polyamidoamine (PAMAM) dendrimer with doxorubicin (DOX) conjugated by acid-sensitive linkage (RGD-PPCD) was a poten... |
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Acid-responsive PEGylated doxorubicin prodrug nanoparticles for neuropilin-1 receptor-mediated targeted drug delivery.
Colloids Surf. B Biointerfaces 136 , 365-74, (2015) Self-assembled prodrug nanoparticles have demonstrated great promise in cancer chemotherapy. In the present study, we developed a new kind of prodrug nanoparticles for targeted drug delivery. PEGylated doxorubicin conjugate with an acid-cleavable cis-aconityl... |
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Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: implications for human neurological disease and immunotherapeutics.
J. Neuroinflammation 6 , 31, (2009) Immunoglobulin G (IgG) antibodies reactive with intracellular neuronal proteins have been described in paraneoplastic and other autoimmune disorders. Because neurons have been thought impermeable to immunoglobulins, however, such antibodies have been consider... |
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Lectin-mediated drug targeting: preparation, binding characteristics, and antiproliferative activity of wheat germ agglutinin conjugated doxorubicin on Caco-2 cells.
Pharm. Res. 15(7) , 1031-7, (1998) To investigate the usefulness of wheat germ agglutinin as a targeting carrier protein for an acid-labile chemotherapeutic prodrug directed against colon carcinoma cells in vitro.Cis-aconityl-linked doxorubicin-wheat germ agglutinin was prepared by a two step ... |
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Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity.
Biochim. Biophys. Acta 1278(2) , 183-90, (1996) Human serum albumin (HSA) derivatized with cis-aconitic anhydride (Aco-HSA) that was earlier shown to inhibit replication of human immunodeficiency virus type 1 (HIV-1), was covalently coupled to conventional liposomes, consisting of phosphatidylcholine, chol... |
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Antiproliferative properties of chemically modified recombinant IFN-alpha2b.
J. Interferon Cytokine Res. 25(7) , 414-7, (2005) The antiproliferative activity of aconitylated (AIFN) and succinylated (SIFN) derivatives of recombinant interferon- alpha2b (IFN-alpha2b) was examined. Acylation of IFN-alpha2b was performed by succinic and cis-aconitic anhydrides. Antiproliferative properti... |
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Tumor reactive cis-aconitylated monoclonal antibodies coupled to daunorubicin through a peptide spacer are unable to kill tumor cells.
Anticancer Res. 10(3) , 845-52, (1990) Antibody-drug conjugates containing a linkage susceptible to lysosomal hydrolases were constructed by coupling peptide-daunorubicin (DNR) derivatives to MAb. Using a modification in the method of Trouet et al, peptide derivatives of DNR containing the sequenc... |
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Daunorubicin coupled to monoclonal antibodies via a cis-aconitic anhydride linker: biochemical and cytotoxic properties revisited.
Anticancer Res. 10(3) , 837-43, (1990) Daunorubicin (DNR) was coupled to monoclonal antibodies (Mab) reactive to breast tumor cells using the acid-labile linking agents cis-asonitic anhydride and two other non acid-labile analogs, glutaric anhydride and citraconic anhydride. The acid derivatives o... |
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Cis-aconitic anhydride ethyl ester and phenolic compounds from the seeds of Alisma orientale.
Nat. Prod. Commun. 7(6) , 785-7, (2012) From the seeds of Alisma orientale, cis-aconitic anhydride ethyl ester and cis-2,4,5-trihydroxycinnamic acid were isolated, together with nine known phenolic compounds and a megastigmane sesquiterpene. All compounds are reported for the first time from Alisma... |