(+)-Muscarine (chloride)
(+)-Muscarine (chloride) structure
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Common Name | (+)-Muscarine (chloride) | ||
|---|---|---|---|---|
| CAS Number | 2303-35-7 | Molecular Weight | 209.71400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H20ClNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.
Mol. Psychiatry 20 , 959-73, (2015) Neuregulin 1 (NRG1) is a trophic factor that has an essential role in the nervous system by modulating neurodevelopment, neurotransmission and synaptic plasticity. Despite the evidence that NRG1 and its receptors, ErbB tyrosine kinases, are expressed in mesen... |
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FRET-based sensors for the human M1-, M3-, and M5-acetylcholine receptors.
Bioorg. Med. Chem. 19 , 1048-54, (2011) Based on the recently developed approach to generate fluorescence resonance energy transfer (FRET)-based sensors to measure GPCR activation, we generated sensor constructs for the human M(1)-, M(3)-, and M(5)-acetylcholine receptor. The receptors were labeled... |
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Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation.
Am. J. Physiol. Cell Physiol. 296 , C1195-206, (2009) Retinal pigmented epithelial cells exchange their cellular phenotypes into lens cells and neurons, via depigmented and non-epithelial-shaped dedifferentiated intermediates. Because these dedifferentiated cells can either revert to pigmented epithelial cells o... |
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Presynaptic effects of muscarine on ACh release at the frog neuromuscular junction.
J. Physiol. London, England 514 , 769-782, (1999) 1. Presynaptic effects of muscarine on neurotransmitter release were studied at the frog neuromuscular junction, using focal depolarization of the presynaptic terminal to different levels. 2. Muscarine (10 microM) had a dual effect on ACh release: concomitant... |
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Brief presentation of the story and present status of studies of the vertebrate cholinergic system.
Neuropsychopharmacology 9 , 181-199, (1993) This year marks the seventieth anniversary of Otto Loewi's demonstration of chemical transmission generally and autonomic cholinergic transmission specifically and the fortieth anniversary of John Eccles's proof of the existence of central cholinergic transmi... |
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Muscarine modulates Ca2+ channel currents in rat sensorimotor pyramidal cells via two distinct pathways.
J. Neurophysiol. 81 , 72-84, (1999) We used the whole cell patch-clamp technique and single-cell reverse transcription-polymerase chain reaction (RT-PCR) to study the muscarinic receptor-mediated modulation of calcium channel currents in both acutely isolated and cultured pyramidal neurons from... |
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Natural products as probes for new drug target identification.
J. Ethnopharmacol. 32 , 91-101, (1991) One traditional aspect of natural products in medical research has been their use in the identification and investigation of the physiological/pathological role of receptors and enzymes as possible targets for drug design programmes. Classical examples of thi... |