Crocin
Crocin structure
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Common Name | Crocin | ||
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| CAS Number | 42553-65-1 | Molecular Weight | 976.965 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 1169.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C44H64O24 | Melting Point | 186° (effervescence) | |
| MSDS | Chinese USA | Flash Point | 337.8±27.8 °C | |
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Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.
Chem. Biol. Interact. 229 , 26-35, (2015) The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulcer group pretreated with crocin, and an ulcer group pretreat... |
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The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo.
J. Ethnopharmacol. 156 , 33-40, (2014) Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoides extract (GJE) elicits anti-allergic effects in mast cell... |
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Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.
J. Thromb. Thrombolysis 38(3) , 321-30, (2014) Recent studies have reported the platelet proapoptotic propensity of plant-derived molecules such as, resveratrol, thymoquinone, andrographolide and gossypol. Meanwhile, there were also reports of phytochemicals such as cinnamtannin B1, which shows antiapopto... |
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Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.
BMC Nephrol. 16 , 50, (2015) In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems t... |
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The protective effect of crocin on the amyloid fibril formation of Aβ42 peptide in vitro.
Cell Mol. Biol. Lett. 18(3) , 328-39, (2013) Aβ is the main constituent of the amyloid plaque found in the brains of patients with Alzheimer's disease. There are two common isoforms of Aβ: the more common form, Aβ40, and the less common but more amyloidogenic form, Aβ42. Crocin is a carotenoid from the ... |
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Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.
Int. J. Mol. Med. 36 , 1291-9, (2015) As intervertebral disc (IVD) degeneration has been proven to contribute to low back pain (LBP), drug treatment aiming at attenuating IVD degeneration may prove to be benefiical. Crocin, a bioactive component of saffron, has been found to exert anti-inflammato... |
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Safranal of Crocus sativus L. inhibits inducible nitric oxide synthase and attenuates asthma in a mouse model of asthma.
Phytother Res. 29(4) , 617-27, (2015) The present study involves evaluation of antioxidant potential of Crocus sativus and its main constituents, safranal (SFN) and crocin (CRO), in bronchial epithelial cells, followed antiinflammatory potential of the active constituent safranal, in a murine mod... |
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Chemo-immunotherapy using saffron and its ingredients followed by E7-NT (gp96) DNA vaccine generates different anti-tumor effects against tumors expressing the E7 protein of human papillomavirus.
Arch. Virol. 160(2) , 499-508, (2015) Saffron and its components have been suggested as promising candidates for cancer prevention. Carotenoids and monoterpene aldehydes are two potent ingredients of saffron. The goal of the current study was to investigate the anti-tumor effect of chemo-immunoth... |
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Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure
Chem. Biol. Interact. 203(3) , 547-55, (2013) Highlights • DZN increased MDA level in the heart of rat and elevated CK-MB activity. • DZN induced histopathological damages in the heart of rat. • DZN induced mitochondria mediated apoptosis in the heart of rat. • Crocin attenuated all toxic effects induced... |
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Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats.
Fitoterapia 83(5) , 888-95, (2012) The current study was designed to evaluate therapeutic potential of systemically administered ethanolic and aqueous extracts of saffron as well as its bioactive ingredients, safranal and crocin, in chronic constriction injury (CCI)-induced neuropathic pain in... |