Cholesterol Chloroformate
Cholesterol Chloroformate structure
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Common Name | Cholesterol Chloroformate | ||
|---|---|---|---|---|
| CAS Number | 7144-08-3 | Molecular Weight | 449.109 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 504.0±20.0 °C at 760 mmHg | |
| Molecular Formula | C28H45ClO2 | Melting Point | 115-117 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 203.1±15.2 °C | |
| Symbol |
GHS05 |
Signal Word | Danger | |
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Novel serum-tolerant lipoplexes target the folate receptor efficiently.
Eur. J. Pharm. Sci. 59 , 83-93, (2014) Gene transfer using non-viral vectors is a promising approach for the safe delivery of nucleic acid therapeutics. In this study, we investigate a lipid-based system for targeted gene delivery to malignant cells overexpressing the folate receptor (FR). Cationi... |
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Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes.
Biomater. Sci. 3 , 1114-23, (2015) In the present study, a series of copolymers (PAMD-Ch) was synthesized by grafting polymeric Plerixafor/AMD3100 (PAMD) with different amounts of cholesterol and the effect of cholesterol modification on siRNA delivery was investigated. PAMD-Ch/siRNA polyplexe... |
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Cholesterol anchored arabinogalactan for asialoglycoprotein receptor targeting: synthesis, characterization, and proof of concept of hepatospecific delivery.
Carbohydr. Res. 408 , 33-43, (2015) Asialoglycoprotein receptors (ASGPR) are hepatocyte bound receptors, which exhibit receptor mediated endocytosis (RME) for galactose specific moieties. Arabinogalactan (AG), a liver specific high galactose containing branched polysaccharide was hydrophobized ... |
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Tumor-specific delivery of siRNA using supramolecular assembly of hyaluronic acid nanoparticles and 2b RNA-binding protein/siRNA complexes.
Biomaterials 35(25) , 7121-32, (2014) Anticancer therapeutics delivering exogenous siRNA have been explored to suppress the tumor-associated genes, but several limitations of siRNA delivery such as tumor-targeted delivery, controlled siRNA release at the sites of interest, or instabilities of siR... |
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New amphiphilic N-phosphoryl oligopeptides designed for gene delivery.
Int. J. Pharm. 468(1-2) , 83-90, (2014) Gene therapy is a potent tool for the treatment of cancer and other gene defect diseases, which involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. However, the DNA transfection efficiency is restricted by its negative ch... |
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Development and in vitro characterization of docetaxel-loaded ligand appended solid fat nanoemulsions for potential use in breast cancer therapy.
Artif. Cells. Nanomed. Biotechnol. 43(2) , 93-102, (2015) Breast cancer accounts for 23% of all newly occurring cancers in women worldwide and represents 13.7% of all cancer deaths. Available chemotherapeutic agents are limited largely due to the low accumulation of chemotherapeutics at the tumors relative to their ... |
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Restoration of chemosensitivity by multifunctional micelles mediated by P-gp siRNA to reverse MDR.
Biomaterials 35(30) , 8621-34, (2014) One of the main obstacles in tumor therapy is multiple drug resistance (MDR) and an underlying mechanism of MDR is up-regulation of the transmembrane ATP-binding cassette (ABC) transporter proteins, especially P-glycoprotein (P-gp). In the synergistic treatme... |
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Noninvasive Imaging of Early Venous Thrombosis by 19F Magnetic Resonance Imaging With Targeted Perfluorocarbon Nanoemulsions.
Circulation 131(16) , 1405-14, (2015) Noninvasive detection of deep venous thrombi and subsequent pulmonary thromboembolism is a serious medical challenge, since both incidences are difficult to identify by conventional ultrasound techniques.Here, we report a novel technique for the sensitive and... |
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Optically binary liquid crystalline blue phases induced by one-armed cholesterol-linked azobenzene molecules.
Soft Matter 11 , 6145-51, (2015) A series of one-armed cholesterol-linked azobenzene molecules named CholXAzo with different spacers were synthesized, in which Chol6Azo was found to have induced blue phases (BPs) with a concentration of 4.0 wt%. Under irradiation of 385 nm UV light with a de... |
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Efficient pDNA Delivery Using Cationic 2-Hydroxypropyl-β-Cyclodextrin Pluronic-Based Polyrotaxanes.
Macromol. Biosci. 16 , 63-73, (2016) A family of cationic Pluronic-based polyrotaxanes (PR(+)), threaded with 2-hydroxypropyl-β-cyclodextrin (HPCD), was synthesized for pDNA delivery into multiple cell lines. All PR(+) formed highly stable, positively charged pDNA complexes that were < 250 nm in... |