alpha-Mangostin
alpha-Mangostin structure
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Common Name | alpha-Mangostin | ||
|---|---|---|---|---|
| CAS Number | 6147-11-1 | Molecular Weight | 410.460 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 640.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H26O6 | Melting Point | 182ºC | |
| MSDS | Chinese USA | Flash Point | 220.3±25.0 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Alpha-mangostin induces changes in glutathione levels associated with glutathione peroxidase activity in rat brain synaptosomes.
Nutr. Neurosci. 15(5) , 13-9, (2012) In a previous report, we have characterized the antiperoxidative properties of alpha-mangostin in different toxic models tested in nerve tissue preparations.Here, the modulatory effects of this xanthone on the glutathione system (reduced glutathione (GSH) lev... |
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A miniaturized flow-through cell to evaluate skin permeation of endoxifen.
Int. J. Pharm. 441(1-2) , 433-40, (2013) Endoxifen, an anti-estrogenic agent, has been recently implicated in the use of breast cancer. Its physicochemical properties make it a good candidate for transdermal delivery. However, as an investigative drug, its limited supply makes it difficult to conduc... |
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Neuroprotective effect of α-mangostin and curcumin against iodoacetate-induced cell death.
Nutr. Neurosci. 15(5) , 34-41, (2012) Curcumin is a phenolic yellow curry pigment with anti-inflammatory and antioxidant activities and α-mangostin is a xanthone isolated from mangosteen fruit with antioxidant properties. Iodoacetate (IAA) is an inhibitor of the glycolytic enzyme glyceraldehyde-3... |
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Α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach.
J. Nat. Prod. 76(4) , 774-8, (2013) α-Mangostin (1) and gambogic acid (2) are natural products with potent cytotoxic activity against several human tumor cells. However, their molecular mechanisms of action remain controversial. In this work, using yeast-based assays, it was shown that both xan... |
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Protective effect of alpha-mangostin against type-I collagen formation in thioacetamide-induced cirrhotic rat.
J. Med. Assoc. Thai. 95 Suppl 12 , S93-8, (2012) To elucidate the protective effect of alpha-mangostin (alpha-MG) against increment of type-I collagen-positive hepatocytes in rat cirrhosis induced by thioacetamide (TAA).Rats were separated into 4 groups. The first group was, the control, untreated with TAA.... |
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Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia.
Dis. Model Mech. 6(1) , 84-94, (2013) Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk. Dietary restriction of galac... |
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Anti-tumorigenicity of dietary α-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites.
Mol. Nutr. Food. Res. 57(2) , 203-11, (2013) This study investigated the in vivo and in vitro activity of α-mangostin (α-MG), the most abundant xanthone in mangosteen pericarp, on HT-29 cell tumorigenicity, proliferation, and several markers of tumor cell activity, as well as the profile and amounts of ... |
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Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting.
Biochim. Biophys. Acta 1828(2) , 834-44, (2013) The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created the need for better therapeutic options. In this study, five natural xanthones were extracted and purified from the fruit hull of Garcinia mangostana and their antimicrobial prope... |
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α-Mangostin induces apoptosis and suppresses differentiation of 3T3-L1 cells via inhibiting fatty acid synthase.
PLoS ONE 7(3) , e33376, (2012) α-Mangostin, isolated from the hulls of Garcinia mangostana L., was found to have in vitro cytotoxicity against 3T3-L1 cells as well as inhibiting fatty acid synthase (FAS, EC 2.3.1.85). Our studies showed that the cytotoxicity of α-mangostin with IC(50) valu... |
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Alterations in cell cycle and induction of apoptotic cell death in breast cancer cells treated with α-mangostin extracted from mangosteen pericarp.
J. Biomed. Biotechnol. 2012 , 672428, (2012) The development of molecularly targeted drugs has greatly advanced cancer therapy, despite these drugs being associated with some serious problems. Recently, increasing attention has been paid to the anticancer effects of natural products. α-Mangostin, a xant... |