Deoxyribonuclease
Deoxyribonuclease structure
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Common Name | Deoxyribonuclease | ||
|---|---|---|---|---|
| CAS Number | 9003-98-9 | Molecular Weight | N/A | |
| Density | 100 g/mL at 20 °C | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.
Cell Death Differ. 22 , 1970-84, (2015) Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinucleated syncytiotrophoblast is a key developmental process requ... |
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ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.
Autophagy 11 , 1308-25, (2015) Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecting the formation of autophagosomes, the post-translational ... |
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Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.
Autophagy 11(1) , 166-82, (2015) The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated through the microbial type III secretion apparatus (T3SS). Rece... |
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Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera.
Infect. Immun. 83(3) , 1089-103, (2015) Vibrio cholerae O1 is a major cause of acute watery diarrhea in over 50 countries. Evidence suggests that V. cholerae O1 may activate inflammatory pathways, and a recent study of a Bangladeshi population showed that variants in innate immune genes play a role... |
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ERK1 and ERK2 present functional redundancy in tetrapods despite higher evolution rate of ERK1.
BMC Evol. Biol. 15 , 179, (2015) The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described, ERK1 and ERK2; ERK2 being regarded by many as essential due to the ... |
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Putting on the brakes: Bacterial impediment of wound healing.
Sci. Rep. 5 , 14003, (2015) The epithelium provides a crucial barrier to infection, and its integrity requires efficient wound healing. Bacterial cells and secretomes from a subset of tested species of bacteria inhibited human and porcine corneal epithelial cell migration in vitro and e... |
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Cystatin C influences the autoimmune but not inflammatory response to cartilage type II collagen leading to chronic arthritis development.
Arthritis. Res. Ther. 13(2) , R54, (2011) Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis (RA) and is induced after immunization with type II collagen (CII). CIA, like RA, is an autoimmune disease leading to destruction of cartilage and joints, and both the priming and infl... |
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Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
Hum. Mol. Genet. 23(18) , 4932-44, (2014) Machado-Joseph Disease (MJD) is the most prevalent autosomal dominantly inherited cerebellar ataxia. It is caused by an expanded CAG repeat in the ATXN3 gene, which translates into a polyglutamine tract within the ataxin-3 protein. Present treatments are symp... |
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Bioengineered multilayered human corneas from discarded human corneal tissue.
Biomed. Mater. 10 , 035012, (2015) Corneal transplantation has become a common procedure to improve visual acuity by replacing the opaque or distorted host tissue with clear healthy donor corneal tissue. However, globally its wide spread clinical utility is limited due to a lack of supply of h... |
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Suppression of endothelial CD39/ENTPD1 is associated with pulmonary vascular remodeling in pulmonary arterial hypertension.
Am. J. Physiol. Lung Cell. Mol. Physiol. 308 , L1046-57, (2015) Endothelial cell (EC) dysfunction plays a role in the pathobiology of occlusive vasculopathy in pulmonary arterial hypertension (PAH). Purinergic signaling pathways, which consist of extracellular nucleotide and nucleoside-mediated cell signaling through spec... |