9003-98-9

9003-98-9 structure

Name: Deoxyribonuclease
Chemical Name: Deoxyribonuclease
CAS Number: 9003-98-9
Molecular Formula:
Molecular Weight:
Catalog: Biochemical Enzymes and coenzymes
Create Date: 2018-02-07 08:00:00
Modify Date: 2025-08-25 11:39:19
Deoxyribonuclease (DNase) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1].

Name	Deoxyribonuclease
Synonyms	Alkaline DNase Alkaline deoxyribonuclease DNA depolymerase DNA endonuclease DNA nuclease DNAase DNase Deoxyribonuclease A Deoxyribonuclease I Deoxyribonucleic phosphatase Desoxyribonuclease Dornase Pancreatic deoxyribonuclease Pancreatic dornase

Description	Deoxyribonuclease (DNase) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	Deoxyribonuclease (0.1 U; i.p.; once daily for 3 days) inhibits liver metastasis, besides results in a greater prolongation of the survival period by combining surgical removal of the primary tumour mass[1]. Animal Model: Female BALB/c x DBA/2 mice with murine tumour L5178Y-ML cells subcutaneous injection[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for three days Result: Reduced liver weight from 2.26 to 1.55 g, affected the intensity of liver metastasis, reduced the numbers and sizes of metastatic and affected tumour cell arrest. Animal Model: Female BALB/c x DBA/2 mice with murine tumour and surgical removal of subcutaneous tumours[1] Dosage: 0.1 U per mouse Administration: Intravenous injection; 0.1 U; once daily for 3 days either before or after primary tumour removal Result: Significantly prolongated survival after tumour cell inoculation compared to the untreated group.

Density	100 g/mL at 20 °C
Appearance	solution (clear, colorless) \| white
Storage condition	−20°C
Water Solubility	Soluble in 0.15 M sodium chloride (5.0mg/L) clear.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	23-24/25-22
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RF0750000