D-Valine,3,3'-dithiobis-
D-Valine,3,3'-dithiobis- structure
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Common Name | D-Valine,3,3'-dithiobis- | ||
|---|---|---|---|---|
| CAS Number | 20902-45-8 | Molecular Weight | 296.40700 | |
| Density | 1.353g/cm3 | Boiling Point | 467ºC at 760mmHg | |
| Molecular Formula | C10H20N2O4S2 | Melting Point | 204ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 236.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Quantification of pipecolic acid in plasma, and of urinary cystine in the presence of penicillamine-cystine disulfide, with the Beckman 6300 amino acid analyzer.
Clin. Chem. 33(7) , 1302-3, (1987)
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Determination of penicillamine, penicillamine disulfide and penicillamine-glutathione mixed disulfide by high-performance liquid chromatography with electrochemical detection.
J. Chromatogr. A. 491(2) , 341-54, (1989) Methodology is described for the simultaneous determination of D-penicillamine, penicillamine disulfide and the penicillamine-glutathione mixed disulfide, as well as glutathione and glutathione disulfide, in human plasma, erythrocytes and urine. The various t... |
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Methods for assaying D-penicillamine in a clinical setting.
Clin. Invest. Med. 7(1) , 31-4, (1984) Penicillamine disulfides have been analysed by automatic amino acid analysis. Because the free thiol reacts poorly with ninhydrin, other detection methods are preferred, particularly high pressure liquid chromatography using an electrochemical detector or gas... |
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Application of high resolution 1H-NMR spectroscopy to the detection of penicillamine and its metabolites in human urine.
Drug Metabol. Drug Interact. 6(3-4) , 439-46, (1988) Preliminary studies on the use of high resolution 1H-NMR spectroscopy for the detection of the thiol drug penicillamine and its metabolites in human urine are described. The technique is rapid, simple and requires minimal sample pretreatment. Application of N... |
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Determination of penicillamine in encapsulated formulations by high-performance liquid chromatography.
J. Chromatogr. A. 318(2) , 404-7, (1985)
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Pharmacokinetics of the major metabolites of D-penicillamine in patients with rheumatoid arthritis.
Clin. Invest. Med. 7(1) , 35-40, (1984) The pharmacokinetic disposition of D-penicillamine and its major metabolites, penicillamine cysteine disulfide ( PSSC ) and penicillamine disulfide ( PSSP ) has been studied in eight patients with rheumatoid arthritis. Plasma concentrations of D-penicillamine... |
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Chronic elemental mercury intoxication: clinical and field studies in lampsocket manufacturers.
Occup. Environ. Med. 51(4) , 267-70, (1994) Four workers chronically exposed to elemental mental mercury in a lampsocket manufacturing factory were studied. The clinical manifestations were severe in one, mild in another, and suspicious in the remaining two. Correlation between severity of clinical fea... |
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An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation.
J. Inorg. Biochem. 101(4) , 594-602, (2007) D-Penicillamine is a potent copper (Cu) chelating agent. D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. It has been proposed that hydrogen peroxide is generated during this process... |
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Penicillamine disulfide (PNS) and alkaline cations.
Ann. Chim. 94(1-2) , 45-56, (2004) D-penicillamine disulfide (PNS) shows protolytic properties and is able to form complexes with cations, because it has two aminic groups and two carboxylic groups. The four protonation constants of its deprotonated species were determined by means of electrom... |
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Understanding base-assisted desulfurization using a variety of disulfide-bridged peptides.
Biopolymers 71(5) , 534-51, (2003) A recently rediscovered reaction of base-assisted lanthionine formation has been applied to several systems of disulfide-bridged peptides. In addition to previously described nonapeptides consisting of i, i+3 cystine linkages, the reaction has now been extend... |