Annali di Chimica 2004-01-01

Penicillamine disulfide (PNS) and alkaline cations.

Fabrizio Apruzzese, Emilio Bottari, Maria Rosa Festa

Index: Ann. Chim. 94(1-2) , 45-56, (2004)

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Abstract

D-penicillamine disulfide (PNS) shows protolytic properties and is able to form complexes with cations, because it has two aminic groups and two carboxylic groups. The four protonation constants of its deprotonated species were determined by means of electromotive force (e.m.f.) measurements of a galvanic cell involving a glass electrode at 25 degrees C and in a constant ionic medium constituted by N(CH3)4Cl 3.00 or 1.00 mol dm-3. At 25 degrees C and in 3.00 mol dm-3 N(CH3)4Cl as ionic medium, equilibria taking place between PNS and lithium, sodium and potassium ions were investigated. Experimental data, again obtained from e.m.f. measurements, were explained by assuming the formation of species of the type MH2PNS ed M2H2PNS, where M indicates a cation. Stability constants for each proposed species were calculated. A comparison with cystine is discussed.