NE 100 hydrochloride
NE 100 hydrochloride structure
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Common Name | NE 100 hydrochloride | ||
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| CAS Number | 149409-57-4 | Molecular Weight | 391.97500 | |
| Density | N/A | Boiling Point | 475.2ºC at 760 mmHg | |
| Molecular Formula | C23H34ClNO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 137.4ºC | |
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Diverse regulation of IP3 and ryanodine receptors by pentazocine through σ1-receptor in cardiomyocytes.
Am. J. Physiol. Heart Circ. Physiol. 305(8) , H1201-12, (2013) Although pentazocine binds to σ1-receptor (σ1R) with high affinity, the physiological relevance of its binding remains unclear. We first confirmed that σ1R stimulation with pentazocine rescues contractile dysfunction following pressure overload (PO)-induced c... |
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A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells
Biochem. Biophys. Res. Commun. 434(4) , 904-9, (2013) Highlights • NE-100 protected neuronal cells against the tunicamycin-induced cell death. • NE-100 attenuated the upregulation of CHOP induced by ER stress. • NE-100 upregulated the expressions of p50ATF6 and GRP78. |
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Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model.
Curr. Drug Metab. 7(2) , 135-46, (2006) The purpose of this study was to propose a new method to predict in vivo drug-drug interactions (DDIs) for a high clearance drug from in vitro data. As the high clearance drug, NE-100 (N, N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine monohydroch... |
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Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor.
J. Neurochem. 119(4) , 839-47, (2011) Chloroquine, a widely used anti-malarial and anti-rheumatoid agent, has been reported to induce apoptotic and non-apoptotic cell death. Accumulating evidence now suggests that chloroquine can sensitize cancer cells to cell death and augment chemotherapy-induc... |
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A novel adamantane derivative attenuates retinal ischemia-reperfusion damage in the rat retina through sigma1 receptors.
Eur. J. Pharmacol. 536(1-2) , 200-3, (2006) The effects of a novel N-methyladamantan-1-amine derivative [(-)-MR22] with high sigma1 receptor affinity were investigated on retinal degeneration using a rat model of ischemia-reperfusion injury. The animals were anaesthetized and retinal ischemia was induc... |
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Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.
Neuroreport 16(11) , 1223-6, (2005) Prolonged exposure of cultured cortical neurons to the residue 25-35 fragment of beta-amyloid protein, in the presence of dizocilpine, an antagonist of the N-methyl-D-aspartate receptor, and of 6,7-dinitroquinoxaline-2,3-dione, an antagonist of alpha-amino-3-... |
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Sigma receptor ligands protect human retinal cells against oxidative stress.
Neuroreport 17(3) , 287-91, (2006) This study was undertaken to investigate the role of sigma receptors during the oxidative damage on human retinal pigment epithelial cells, and to assess whether sigma receptor ligands enhance survival and protect DNA of cells challenged by oxidative stress. ... |
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Differences in the allosteric modulation by phenytoin of the binding properties of the sigma1 ligands [3H](+)-pentazocine and [3H]NE-100.
Synapse 59(3) , 152-61, (2006) The present study evaluated the effects of phenytoin (DPH) on the binding to synaptosomal fraction membranes from guinea pig brain of the prototypic sigma1 (sigma1) receptor agonist [3H](+)-pentazocine and the putative sigma1 antagonist [3H]NE-100. Equilibriu... |
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Improvement of memory impairment by (+)- and (-)-pentazocine via sigma, but not kappa opioid receptors.
Brain Res. 1057(1-2) , 72-80, (2005) (+/-)-Pentazocine is widely used clinically to treat mild to moderate pain as a racemic compound. Although it is known that (-)-pentazocine acts as a kappa opioid receptor agonist to exhibit analgesic actions and (+)-pentazocine acts as a sigma receptor agoni... |
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Targeting sigma-1 receptor with fluvoxamine ameliorates pressure-overload-induced hypertrophy and dysfunctions.
Expert Opin. Ther. Targets 14(10) , 1009-22, (2010) We here investigated the effect of sigma-1 receptor (Sig-1R) stimulation with fluvoxamine on myocardial hypertrophy, cardiac functional recovery and defined mechanisms underlying its cardioprotective action.Wistar rats subjected to bilateral ovariectomy (OVX)... |