Biochemical and Biophysical Research Communications 2013-05-17

A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells

Yoko Ono, Hirotaka Tanaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara

Index: Biochem. Biophys. Res. Commun. 434(4) , 904-9, (2013)

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Abstract

Highlights • NE-100 protected neuronal cells against the tunicamycin-induced cell death. • NE-100 attenuated the upregulation of CHOP induced by ER stress. • NE-100 upregulated the expressions of p50ATF6 and GRP78.