Indole-5-carboxaldehyde
Indole-5-carboxaldehyde structure
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Common Name | Indole-5-carboxaldehyde | ||
|---|---|---|---|---|
| CAS Number | 1196-69-6 | Molecular Weight | 145.158 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 339.1±15.0 °C at 760 mmHg | |
| Molecular Formula | C9H7NO | Melting Point | 100-103 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 166.8±27.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Synthesis and antifungal activity of novel streptochlorin analogues.
Eur. J. Med. Chem. 92 , 776-83, (2015) Streptochlorin, first isolated as a new antibiotic in 1988 from the lipophilic extracts of the mycelium of a Streptomyces sp, is an indole natural products with a variety of biological activities. Based on the methods developed for the synthesis of pimprinine... |
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Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization.
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Synthesis and biological evaluation of achiral indole-substituted titanocene dichloride derivatives.
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Synthesis and structure-affinity relationships of novel dibenzylideneacetone derivatives as probes for β-amyloid plaques.
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Amyloid-β probes: Review of structure-activity and brain-kinetics relationships.
Beilstein J. Org. Chem. 9 , 1012-44, (2013) The number of people suffering from Alzheimer's disease (AD) is expected to increase dramatically in the coming years, placing a huge burden on society. Current treatments for AD leave much to be desired, and numerous research efforts around the globe are foc... |
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Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors Through Rational Design.
ACS Chem. Neurosci. 2 , 288, (2011) Botulinum neurotoxin (BoNT), the etiological agent that causes the neuroparalytic disease botulism, has become a highly studied drug target in light of the potential abuse of this toxin as a weapon of bioterrorism. In particular, small molecule inhibitors of ... |
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Curcumin analogues as possible anti-proliferative & anti-inflammatory agents.
Eur. J. Med. Chem. 46 , 2722, (2011) A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in vivo as potential multi-target agents. Their anti-proliferative and anti-inflammatory activities were studied. Compounds 1b and 2b were stronger inhibitors of soybean l... |
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Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.
J. Med. Chem. 52 , 1050, (2009) Aurora kinases have emerged as attractive targets for the design of anticancer drugs. Through structure-based virtual screening, novel pyrazole hit 8a was identified as Aurora kinase A inhibitor (IC(50) = 15.1 microM). X-ray cocrystal structure of 8a in compl... |
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Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.
Bioorg. Med. Chem. Lett. 10 , 719, (2000) A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydroge... |
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Catalytic asymmetric synthesis of protected tryptophan regioisomers.
J. Org. Chem. 67 , 6256, (2002) Tryptophan 1 (Trp) is superior to all other naturally occurring peptide residues in its ability to bind cations (the cation-pi interaction). In an effort to expand the toolbox of Trp-like amino acids, in this note we report catalytic asymmetric syntheses of T... |