N-Butylurea
N-Butylurea structure
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Common Name | N-Butylurea | ||
|---|---|---|---|---|
| CAS Number | 592-31-4 | Molecular Weight | 116.16200 | |
| Density | 0.962 g/cm3 | Boiling Point | 179.4ºC at 760 mmHg | |
| Molecular Formula | C5H12N2O | Melting Point | 95-98 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 62.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A quadruply hydrogen bonded heterocomplex displaying high-fidelity recognition.
J. Am. Chem. Soc. 127(51) , 18133-42, (2005) An exceptionally strong quadruply hydrogen-bonded complex is formed between 2,7-diamido-1,8-naphthyridine 3 (DAN) and the butylurea of guanosine 6 (UG) in chloroform. The UG unit can be prepared in four steps from guanosine on a 10 g scale in excellent yields... |
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Comparative evaluation of fifteen anti-sickling agents.
Blood 61(4) , 693-704, (1983) Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) ... |
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Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease.
Bioorg. Med. Chem. 11(22) , 4769-77, (2003) The human immunodeficiency virus (HIV) has been shown to be the causative agent for AIDS. The HIV virus encodes for a unique aspartyl protease that is essential for the production of enzymes and proteins in the final stages of maturation. Protease inhibitors ... |
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Inhibition of HIV-1 infection by alkylureas.
AIDS 5(12) , 1447-52, (1991) The risk of infection by HIV-1 through transfusion of contaminated blood products has been markedly decreased but not eliminated by serological screening of donors. Methods are required to further minimize or eliminate the risk of infection of blood product r... |
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Chalcogens as terminal ligands to iron: synthesis and structure of complexes with Fe(III)-S and Fe(III)-Se motifs.
J. Am. Chem. Soc. 126(21) , 6522-3, (2004) Metal complexes with terminal chalcogenido ligands are known for the early transition-metal complexes, yet for the heavier congeners (e.g., sulfido and selenido), there are no analogous examples for the late 3d metal ions. Reported herein is the isolation and... |
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Mechanistic studies on hydrotropic solubilization of nifedipine in nicotinamide solution.
Chem. Pharm. Bull. 46(1) , 125-30, (1998) Nicotinamide is a hydrotropic agent that has been demonstrated to solubilize a wide variety of drugs through complexation. Past investigations on the potential interaction of nicotinamide with a solubilized drug have inadequately focused on aliphatic hydrotro... |
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Tumor induction by a single subcutaneous injection of 1-butyl-1-nitrosourea or 1-butylurea in newborn mice.
Cancer Lett. 18(3) , 321-8, (1983) A subcutaneous injection of 1-butyl-1-nitrosourea (BNU) at the maximum tolerated dose (333 mg/kg body wt.) to newborn CDF1 mice induced adenocarcinoma and adenoma of the lung, adenoma of the liver, thymic or non-thymic lymphoma and neurinoma of the acusticus ... |
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Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
Bioorg. Med. Chem. 16(4) , 1874-83, (2008) Starting from a pentapeptide Hepatitis C virus NS3 protease inhibitor, a number of alpha-ketoamide inhibitors based on novel dichlorocyclopropylproline P2 core were synthesized and investigated for their HCV NS3 serine protease activity. The key intermediate ... |
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Thermodynamics of anti-sickling agents with hemoglobin S.
J. Mol. Biol. 150(3) , 423-34, (1981)
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Preclinical studies of alkylureas as anti-HIV-1 contraceptive.
Curr. Pharm. Des. 11(29) , 3769-78, (2005) The HIV-1 epidemic continues to spread at a rate of over 15, 000 new cases daily. HIV-1 transmission through heterosexual contact became the dominant risk for women globally. About half of the over 40 million HIV-1 infected individuals worldwide are now women... |