1,3-Dichloroacetone
1,3-Dichloroacetone structure
|
Common Name | 1,3-Dichloroacetone | ||
|---|---|---|---|---|
| CAS Number | 534-07-6 | Molecular Weight | 126.969 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 173.0±0.0 °C at 760 mmHg | |
| Molecular Formula | C3H4Cl2O | Melting Point | 43 °C | |
| MSDS | Chinese USA | Flash Point | 89.4±0.0 °C | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
|
An evaluation of the chick cardiomyocyte micromass system for identification of teratogens in a blind trial
Reprod. Toxicol. 28(4) , 503-10, (2009) The chick micromass culture system has advantages over the validated rat system – ready availability and non-culling of the donor parent – but needs to give comparable results. This study confirmed comparability and the ability to extend the system to cover c... |
|
|
In vitro metabolism and bioactivation of 1,2,3-trichloropropane.
Toxicol. Appl. Pharmacol. 113(1) , 152-8, (1992) In vitro studies using rat and human hepatic microsomes have shown that the halogenated hydrocarbon 1,2,3-trichloropropane (TCP) is bioactivated to the direct acting mutagen 1,3-dichloroacetone (DCA). The presence of DCA in microsomal incubations was confirme... |
|
|
Effects of pH and temperature on the degradation of chloroacetones that are mutagenic.
Bull. Environ. Contam. Toxicol. 39(3) , 549-54, (1987)
|
|
|
Studies of the toxic interactions of disinfection by-products.
Environ. Health Perspect. 69 , 203-7, (1986) A large number and variety of compounds are formed in the process of chlorinating drinking water. The classes of compounds formed include trihalomethanes, haloacetic acids, haloacetonitriles, halophenols, and halopropanones. Many of the compounds have been sh... |
|
|
Chemical reactivity, cytotoxicity, and mutagenicity of chloropropanones.
Toxicol. Appl. Pharmacol. 91(1) , 46-54, (1987) Studies were conducted to assess the in vitro toxicity of three chloropropanones: monochloropropanone (MCP), 1,1-dichloropropanone (1,1-DCP), and 1,3-dichloropropanone (1,3-DCP). Chloropropanones reacted directly with reduced glutathione (GSH) in sodium phosp... |
|
|
Carcinogenic activity associated with halogenated acetones and acroleins in the mouse skin assay.
Cancer Lett. 48(3) , 197-203, (1989) Several chlorinated acetones have been identified in drinking water and these, as well as a number of chlorinated acroleins, are produced by chlorination of humic acid solutions. Many of these chlorinated compounds and the brominated acrolein analog were posi... |
|
|
Modulation of hepatocyte thiol content by medium composition: implications for toxicity studies.
Toxicol. In Vitro 16(3) , 259-65, (2002) Toxicity of compounds requiring glutathione for detoxification, thiol content and synthesis were determined in 24-h rat hepatocytes cultured in medium containing different concentrations of the sulphur amino acids. Glutathione synthesis was determined followi... |
|
|
Haloalcohols deplete glutathione when incubated with fortified liver fractions.
Xenobiotica 29(5) , 533-45, (1999) 1. This study has examined the ability of dichloropropanols, haloalcohols and their putative metabolites to deplete glutathione when incubated with liver fractions obtained from untreated and differentially induced rats. 2. 1,3-Dichloropropan-2-ol and 2,3-dic... |
|
|
Involvement of cytochrome P4502E1 in the toxicity of dichloropropanol to rat hepatocyte cultures.
Toxicology 118(2-3) , 171-9, (1997) Hepatocytes were isolated and cultured from untreated rats and rats treated with isoniazid to induce cytochrome P4502E1. Isoniazid selectively increased p-nitrophenol hydroxylase activity in 2-h cultures, and increased the toxicity of both 1,3- and 2,3-dichlo... |
|
|
Samarium Ion-Promoted Cross-Aldol Reactions and Tandem Aldol/Evans-Tishchenko Reactions.
J. Org. Chem. 64(3) , 843-853, (1999) Cross-aldol reactions of carbonyl compounds were achieved by the catalysis of SmI(2) or SmI(3), together with molecular sieves, at ambient temperature. 1,3-Dichloroacetone and 1-chloroacetone can be used as acceptor substrates in the cross-aldol reactions wit... |