fenspiride hydrochloride
fenspiride hydrochloride structure
|
Common Name | fenspiride hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 5053-08-7 | Molecular Weight | 296.79200 | |
| Density | 1.19g/cm3 | Boiling Point | 474.3ºC at 760mmHg | |
| Molecular Formula | C15H21ClN2O2 | Melting Point | 235-238ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 240.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Fenspiride and membrane transduction signals in rat alveolar macrophages.
Biochem. Pharmacol. 54 , 293, (1997) Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic range (approximately 1 microM). Here, in rat alveolar macrophag... |
|
|
Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study.
Eur. J. Pharmacol. 341 , 79, (1998) We have investigated the role of human bronchial cyclic nucleotide phosphodiesterases in the effects of fenspiride, a drug endowed with bronchodilator and anti-inflammatory properties. Functional studies on human isolated bronchi showed that fenspiride (10(-6... |
|
|
Fenspiride inhibits histamine-induced responses in a lung epithelial cell line.
Eur. J. Pharmacol. 348 , 297-304, (1998) Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced intracellular Ca2+ increase and eicosanoid formation. Histami... |