fenspiride hydrochloride structure
|
Common Name | fenspiride hydrochloride | ||
---|---|---|---|---|
CAS Number | 5053-08-7 | Molecular Weight | 296.79200 | |
Density | 1.19g/cm3 | Boiling Point | 474.3ºC at 760mmHg | |
Molecular Formula | C15H21ClN2O2 | Melting Point | 235-238ºC (dec.) | |
MSDS | Chinese USA | Flash Point | 240.6ºC | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of fenspiride hydrochlorideFenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors. |
Name | 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one,hydrochloride |
---|---|
Synonym | More Synonyms |
Description | Fenspiride Hcl is an α adrenergic and H1 histamine receptor antagonist.IC50 value:Target: Adrenergic receptor; H1 receptorFenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. Fenspiride hydrochloride inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level. Fenspiride hydrochloride also may be an antagonist at α adrenergic and H1 histamine receptors. |
---|---|
Related Catalog | |
References |
[5]. Fenspiride |
Density | 1.19g/cm3 |
---|---|
Boiling Point | 474.3ºC at 760mmHg |
Melting Point | 235-238ºC (dec.) |
Molecular Formula | C15H21ClN2O2 |
Molecular Weight | 296.79200 |
Flash Point | 240.6ºC |
Exact Mass | 296.12900 |
PSA | 41.57000 |
LogP | 2.87220 |
Appearance of Characters | powder | white |
Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
---|---|
Signal Word | Warning |
Hazard Statements | H302-H312-H332 |
Precautionary Statements | P280 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn |
Risk Phrases | 20/21/22 |
Safety Phrases | 36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | RO0375000 |
Fenspiride and membrane transduction signals in rat alveolar macrophages.
Biochem. Pharmacol. 54 , 293, (1997) Fenspiride inhibits the calcium signal evoked by the inflammatory peptide formyl-Met-Leu-Phe (fMLP) in peritoneal macrophages, but at concentrations (approximately 1 mM) far above the therapeutic rang... |
|
Effects of fenspiride on human bronchial cyclic nucleotide phosphodiesterase isoenzymes: functional and biochemical study.
Eur. J. Pharmacol. 341 , 79, (1998) We have investigated the role of human bronchial cyclic nucleotide phosphodiesterases in the effects of fenspiride, a drug endowed with bronchodilator and anti-inflammatory properties. Functional stud... |
|
Fenspiride inhibits histamine-induced responses in a lung epithelial cell line.
Eur. J. Pharmacol. 348 , 297-304, (1998) Using the human lung epithelial WI26VA4 cell line, we investigated the capacity of fenspiride, an anti-inflammatory drug with anti-bronchoconstrictor properties, to interfere with histamine-induced in... |
Fenspiride (Hydrochloride) |
Fenspiride HCl |
NDR-5998A |
Depiride |
Fluiden |
Pneumorel |
Tegencia hydrochloride |
Viarespan hydrochloride |
Espiran |
8-(2-Phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride |
fenspiride hydrochloride |