trolamine salicylate
trolamine salicylate structure
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Common Name | trolamine salicylate | ||
|---|---|---|---|---|
| CAS Number | 2174-16-5 | Molecular Weight | 287.309 | |
| Density | 1.209 g/mL at 25 °C | Boiling Point | 335.4ºC at 760mmHg | |
| Molecular Formula | C13H21NO6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 113 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Topical penetration of commercial salicylate esters and salts using human isolated skin and clinical microdialysis studies.
Br. J. Clin. Pharmacol. 46(1) , 29-35, (1998) The penetration of active ingredients from topically applied anti-inflammatory pharmaceutical products into tissues below the skin is the basis of their therapeutic efficacy. There is still controversy as to whether these agents are capable of direct penetrat... |
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Serum concentrations of salicylic acid following topically applied salicylate derivatives.
Ann. Pharmacother. 30(9) , 935-40, (1996) To compare the rate and extent of systemic salicylate absorption following single and multiple applications of two topically applied analgesics, one containing methyl salicylate and the other containing trolamine salicylate.Two-period, two-treatment, randomiz... |
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Self promotion of deep tissue penetration and distribution of methylsalicylate after topical application.
Pharm. Res. 16(3) , 427-33, (1999) To determine how changes in cutaneous blood flow induced in-vivo by methylsalicylate (MeSA), compared to non-rubefacient triethanolamine salicylate (TSA), affected topical salicylate absorption and distribution, and to assess formulation therapeutic potential... |
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Trolamine salicylate cream in osteoarthritis.
JAMA 248(13) , 1577-8, (1982)
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Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats.
Arch. Facial Plast. Surg. 1(1) , 27-32, (1999) To determine the efficacy of topical anti-ischemic drug therapy in the salvage of failing, random-pattern skin flaps.Prospective, randomized, placebo-controlled, therapeutic trial.Academic medical center.Sixty-one adult male Sprague-Dawley rats.Each experimen... |
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Trolamine salicylate cream in osteoarthritis of the knee.
JAMA 247(9) , 1311-3, (1982) Twenty-five patients with symptomatic osteoarthritis (OA) of the knee were treated topically for one week with either 10% trolamine salicylate cream or placebo cream in a randomized double-blind crossover study. No significant difference was found in subjecti... |
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Penetration of trolamine salicylate into the skeletal muscle of the pig.
J. Pharm. Sci. 73(7) , 1002-4, (1984) Studies to determine the extent of local tissue penetration of topically applied trolamine [14C]salicylate were conducted in domestic pigs. The preparation was applied onto a 100-cm2 shaved area of skin overlying the biceps femoris at a concentration of 0.7 m... |
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Comparative tissue absorption of oral 14C-aspirin and topical triethanolamine 14C-salicylate in human and canine knee joints.
J. Clin. Pharmacol. 22(1) , 42-8, (1982) The local, articular, and systemic absorption of oral and topical salicylates was studied in dogs and humans using radioisotope techniques. Topical triethanolamine 14C-salicylate was found capable of percutaneous absorption into the knee joint and surrounding... |
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Assessment of triethanolamine salicylate release from the dermatological bases and the commercial products.
Pharm. Acta Helv. 66(12) , 322-8, (1991) Recently, triethanolamine salicylate (TEAS) is frequently being incorporated in several over-the-counter topical analgesic pharmaceutical products. Since the clinical efficacy of such dosage form depends upon the release of the active ingredient at the site o... |
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Effects of ultrasound and trolamine salicylate phonophoresis on delayed-onset muscle soreness.
Phys. Ther. 71(9) , 666-75; discussion 675-8, (1991) The purpose of this study was to determine the effects of ultrasound and phonophoresis using an anti-inflammatory-analgesic cream (trolamine salicylate) on delayed-onset muscle soreness (DOMS). Repeated eccentric contractions were used to induce DOMS in the e... |