J L Rabinowitz, E S Feldman, A Weinberger, H R Schumacher
Index: J. Clin. Pharmacol. 22(1) , 42-8, (1982)
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The local, articular, and systemic absorption of oral and topical salicylates was studied in dogs and humans using radioisotope techniques. Topical triethanolamine 14C-salicylate was found capable of percutaneous absorption into the knee joint and surrounding tissues. In dogs, topical salicylate application resulted in higher salicylate concentrations than oral aspirin in a number of tissues, despite lower blood levels. In patients with rheumatoid arthritis, intraarticular 14C-salicylate levels after triethanolamine 14C-salicylate cream were 60 per cent of those obtained with oral aspirin. Four of six patients reported equal improvement in local discomfort after oral and topical salicylates. A potential role for topical salicylate cream in the treatment of localized rheumatic disorders is suggested.
Structure | Name/CAS No. | Molecular Formula | Articles |
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trolamine salicylate
CAS:2174-16-5 |
C13H21NO6 |
Topical penetration of commercial salicylate esters and salt...
1998-07-01 [Br. J. Clin. Pharmacol. 46(1) , 29-35, (1998)] |
Serum concentrations of salicylic acid following topically a...
1996-09-01 [Ann. Pharmacother. 30(9) , 935-40, (1996)] |
Self promotion of deep tissue penetration and distribution o...
1999-03-01 [Pharm. Res. 16(3) , 427-33, (1999)] |
Trolamine salicylate cream in osteoarthritis.
1982-10-01 [JAMA 248(13) , 1577-8, (1982)] |
Comparison of topical anti-ischemic agents in the salvage of...
1999-01-01 [Arch. Facial Plast. Surg. 1(1) , 27-32, (1999)] |
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