4-hydroxyisobenzofuran-1,3-dione
4-hydroxyisobenzofuran-1,3-dione structure
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Common Name | 4-hydroxyisobenzofuran-1,3-dione | ||
|---|---|---|---|---|
| CAS Number | 37418-88-5 | Molecular Weight | 164.12 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 365.4±25.0 °C at 760 mmHg | |
| Molecular Formula | C8H4O4 | Melting Point | 199-202 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 160.2±16.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The antiviral activity of naturally occurring proteins and their peptide fragments after chemical modification.
Antiviral Res. 59(1) , 23-33, (2003) Chemical modification of the proteins bovine serum albumin, alpha-lactalbumin, beta-lactoglobulin and chicken lysozyme by 3-hydroxyphthalic anhydride (3-HP) yielded compounds which exerted antiviral activity in vitro as compared with the native unmodified pro... |
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[Antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin against herpes simplex virus 2 in vitro].
Nan Fang Yi Ke Da Xue Xue Bao 31(7) , 1175-8, (2011) To investigate the antiviral activity of 3-hydroxyphthalic anhydride-modified ovalbumin (HP-OVA) against herpes simplex virus 2 (HSV-2) in vitro.By chemical modification, ovalbumin (OVA) was treated with 3-hydroxyphthalic anhydride (HP) to prepare HP-OVA. The... |
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3-hydroxyphthalic anhydride-modified chicken ovalbumin exhibits potent and broad anti-HIV-1 activity: a potential microbicide for preventing sexual transmission of HIV-1.
Antimicrob. Agents Chemother. 54(5) , 1700-11, (2010) Heterosexual transmission is the primary route by which women acquire human immunodeficiency virus (HIV)/AIDS. Thus, development of woman-controlled topical microbicides for prevention of sexual transmission of HIV is urgently needed. Here we report that 3-hy... |
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3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry.
J. Antimicrob. Chemother. 68(3) , 573-6, (2013) We recently demonstrated that both 3-hydroxyphthalic anhydride (HP)- and maleic anhydride-modified chicken ovalbumin (OVA) could effectively inhibit HIV-1 infection. But because OVA may cause allergy in some human subjects, here we replaced OVA with human ser... |
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Combinations of 3-hydroxyphthalic anhydride-modified ovalbumin with antiretroviral drug-based microbicide candidates display synergistic and complementary effects against HIV-1 infection.
J. Acquir. Immune Defic. Syndr. 56(5) , 384-92, (2011) The development of a safe, effective, and affordable microbicide to prevent the sexual transmission of HIV combination is urgently needed. Our previous studies demonstrated that 3-hydroxyphthalic anhydride-modified chicken ovalbumin (HP-OVA) exhibited potent ... |