Oxatomide
Oxatomide structure
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Common Name | Oxatomide | ||
|---|---|---|---|---|
| CAS Number | 60607-34-3 | Molecular Weight | 426.55300 | |
| Density | 1.175 g/cm3 | Boiling Point | 621.1ºC at 760 mmHg | |
| Molecular Formula | C27H30N4O | Melting Point | 153.60C | |
| MSDS | Chinese USA | Flash Point | 329.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast.
Drugs 69(18) , 2541-76, (2009) Allergic rhinitis (AR) affects a large percentage of paediatric patients. With the wide array of available agents, it has become a challenge to choose the most appropriate treatment for patients. Second-generation antihistamines have become increasingly popul... |
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Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.
Biochem. Pharmacol. 91(2) , 231-41, (2014) Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and sec... |
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Molecular complexes of ketaconazole and oxatomide with p-chloranil: spectroscopic and spectrofluorimetric studies.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 79(5) , 1137-44, (2011) The molecular complexes of the donors ketaconazole (KTZ) and oxatomide (OXA) drugs with 2,3,5,6-tetrachloro-1,4-benzoquinone (p-chloranil, p-CHL) have been investigated spectroscopically (UV-vis, FT-IR and 1H NMR) and spectrofluorimetrically in different solv... |
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High-performance liquid chromatographic determination of oxatomide and its metabolite and its application to pharmacokinetic study in rat plasma.
Arzneimittelforschung 52(10) , 754-63, (2002) Oxatomide (CAS 60607-34-3) is an antiallergic agent effective against allergic rhinitis, urticaria, pruritus dermatitis, eczema dermatitis and bronchial asthma. The aim of this study was to establish the method for simultaneously determining oxatomide and its... |
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Effect of oxatomide, an antiallergic agent, on QT interval in dogs.
Arzneimittelforschung 51(12) , 971-6, (2001) Oxatomide (CAS 60607-34-3, KW-4354) is an effective antiallergic agent for allergic rhinitis, urticaria, pruritus cutaneous, and eczema/dermatitis, etc. Terfenadine (CAS 50679-08-8) and astemizole (CAS 68844-77-9), antiallergic agents, have been reported to i... |
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[Atopic dermatitis: role of oxatomide].
Ann. Dermatol. Venereol. 117 Suppl 1 , 15-9, (1990) Oxatomide is an antiallergic molecule which acts mainly as a calcium blocker. This article is a review of oxatomide treatment in atopic dermatitis patients. First, an overview of oxatomide treatment hypersensitivity reactions in atopic dermatitis and of their... |
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Severe cholinergic urticaria successfully treated with scopolamine butylbromide in addition to antihistamines.
Clin. Exp. Dermatol. 31(4) , 588-9, (2006)
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Solvent effect on the charge transfer complex of oxatomide with 2,3-dichloro-5,6-dicyanobenzoquinone.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 65(5) , 1148-53, (2006) The charge transfer complex (CT-complex) between oxatomide drug and 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) was studied spectrophotometrically in 10 solvents at different temperatures. The donor oxatomide is found to form stable 1:1 stoichiometric complex ... |
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The antiallergic drug oxatomide promotes human eosinophil apoptosis and suppresses IL-5-induced eosinophil survival.
J. Allergy Clin. Immunol. 111(3) , 567-72, (2003) Eosinophils accumulated in sites of allergic inflammation are thought to play a crucial role in the pathogenesis of allergic disorders including asthma, allergic rhinitis, and atopic dermatitis, and tissue eosinophilia is attributable to increased eosinophil ... |
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The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis.
Ann. Allergy Asthma Immunol. 89(6) , 589-98, (2002) There has been no study comparing the long-term effects of ketotifen, oxatomide, and cetirizine for the treatment of perennial allergic rhinitis among children.We conducted a study to compare the efficacy of the three agents for the treatment of perennial all... |