Prostaglandin B1
Prostaglandin B1 structure
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Common Name | Prostaglandin B1 | ||
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| CAS Number | 13345-51-2 | Molecular Weight | 336.47 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 531.4±43.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O4 | Melting Point | 69-71°C(lit.) | |
| MSDS | Chinese USA | Flash Point | 289.2±24.7 °C | |
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NADP(+)-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification.
Free Radic. Biol. Med. 83 , 66-76, (2015) An NADP(+)-dependent dehydrogenase activity on 3-glutathionyl-4-hydroxynonanal (GSHNE) was purified to electrophoretic homogeneity from a line of human astrocytoma cells (ADF). Proteomic analysis identified this enzymatic activity as associated with carbonyl ... |
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A novel synthesis of racemic and enantiomeric forms of prostaglandin B1 methyl ester.
J. Org. Chem. 65(17) , 5127-30, (2000) 3-(Dimethoxyphosphorylmethyl)cyclopent-2-enone was converted into (+/-)-prostaglandin B1 methyl ester in two steps involving regioselective alkylation at C(2) with methyl 7-iodoheptanoate and subsequent Horner-Wittig reaction with dimer of 2-hydroxyheptanal (... |
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Prostaglandin B1 can modify the pressor responses to sympathetic nerve stimulation.
Res. Commun. Chem. Pathol. Pharmacol. 41(3) , 397-405, (1983) PGB1, a metabolite of PGA1, has the ability to enhance peripheral vascular resistance and elevate blood pressure in animals whose vascular tone is low. The effect is not central in origin and apparently is not the result of changes in cholinergic or alpha-adr... |
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Biophysical studies on molecular mechanism of abortificient action of prostaglandins-IV. Conformation energy calculation of PGA1, PGB1 and PGE1.
J. Theor. Biol. 94(4) , 943-9, (1982)
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The effect of NaCl intake on 9-ketoprostaglandin reductase activity in the rabbit kidney.
Prostaglandins 30(2) , 335-49, (1985) Renal 9-ketoprostaglandin reductase activity from rabbits fed 0.3 g or 2.5 g NaCl per 100 g chow was measured in both centrifuged homogenates and in purified enzyme fractions. There was no salt related increase in 9-ketoprostaglandin reductase activity. PGA1-... |
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The percutaneous penetration of prostaglandin E1 and its alkyl esters.
J. Control. Release 58(3) , 349-55, (1999) The percutaneous delivery of PGE1 and its alkyl esters in alcoholic saline solution through hairless mouse skin was compared. The quantification of alkyl esters was based on the same principle as that for PGE1, which was converted to PGB1 to enhance the sensi... |
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Role of calcium in prostaglandin induced contractile activity in rat uterus.
Indian J. Med. Res. 80 , 491-3, (1984)
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Polymeric prostaglandin PGBx and other prostaglandin polymers prolong survival of the heart of the hypoxic mouse.
Aviat. Space. Environ. Med. 54(5) , 420-4, (1983) A new chemical method for prolongation of survival under hypoxia is reported. Polymeric prostaglandin PGBx which shows beneficial effects on damaged mitochondria in vitro was used. Survival time of the intact hypoxic (6% O2) mouse as measured by electrocardio... |
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Effect of oligomeric derivatives of prostaglandin B1 on oxidative phosphorylation and their Ca2+ ionophoretic activity.
Biochem. Biophys. Res. Commun. 137(1) , 215-21, (1986) Dimers, trimers and tetramers of 15-dehydro-PGB1 and of 16,16'-dimethyl-15-dehydro-PGB1 have been synthesized and their effect on mitochondrial function evaluated. The trimers and tetramers, and to a lesser extent the dimers, of both series, protected isolate... |
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Inhibition of human phospholipases A2 by cis-unsaturated fatty acids and oligomers of prostaglandin B1.
Adv. Exp. Med. Biol. 279 , 219-30, (1990) Inhibition of human phospholipases A2 by cis-unsaturated fatty acids and their oxidative metabolites and/or polymers was studied using partially purified human phospholipases A2 and [1-14C]oleate labelled, autoclaved E. coli as substrate. As previously report... |