5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate
5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate structure
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Common Name | 5-(and-6)-carboxy-2`,7`-dichlorofluorescein diacetate | ||
|---|---|---|---|---|
| CAS Number | 127770-45-0 | Molecular Weight | 529.279 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 743.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C25H14Cl2O9 | Melting Point | 210ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 403.3±32.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A high throughput in vitro mrp2 assay to predict in vivo biliary excretion.
Xenobiotica 42 , 157-163, (2012) Prediction of biliary excretion is a challenge for drug discovery scientists due to the lack of in vitro assays. This study explores the possibility of establishing a simple assay to predict in vivo biliary excretion via the mrp2 transport system. In vitro mr... |
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Impact of probe compound in MRP2 vesicular transport assays.
Eur. J. Pharm. Sci. 46 , 100-105, (2012) MRP2 is an efflux transporter that is expressed mainly in the canalicular membrane of hepatocytes, where it expels polar and ionic compounds into the bile. MRP2 is also present in the apical membrane of enterocytes and epithelial cells of proximal tubules of ... |
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Molecular analysis of the yeast VPS3 gene and the role of its product in vacuolar protein sorting and vacuolar segregation during the cell cycle.
J. Cell Biol. 111 , 877, (1990) vps3 mutants of the yeast Saccharomyces cerevisiae are impaired in the sorting of newly synthesized soluble vacuolar proteins and in the acidification of the vacuole (Rothman, J. H., and T. H. Stevens. Cell. 47:1041-1051; Rothman, J. H., C. T. Yamashiro, C. K... |
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Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites.
Toxicol. Appl. Pharmacol. 263 , 244-250, (2012) We previously reported a quantitative time-lapse imaging (QTLI)-based analysis method to assess drug-drug interactions (DDI) at multidrug resistance-associated protein 2 (Mrp2) in rat sandwich-cultured hepatocyte (SCH) system, utilizing the fluorescent Mrp2 s... |
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Characterization of rhodamine-123, calcein and 5(6)-carboxy-2',7'-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.
Eur. J. Pharm. Sci. 43 , 359-369, (2011) Based on our initial results on the effects of several ATP-binding cassette (ABC) transporter inhibitors on rhodamine-123 efflux from A549, a human lung carcinoma, and MES-SA, a human uterine sarcoma cell line, the aim of this study was to identify the transp... |