CRT0044876
CRT0044876 structure
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Common Name | CRT0044876 | ||
|---|---|---|---|---|
| CAS Number | 6960-45-8 | Molecular Weight | 206.155 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 520.8±30.0 °C at 760 mmHg | |
| Molecular Formula | C9H6N2O4 | Melting Point | 260-261 °C | |
| MSDS | Chinese USA | Flash Point | 268.8±24.6 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy.
Nucleic Acids Res. 42(5) , 3089-103, (2014) Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents. Despite their frequency, the overlapping mechanism... |
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APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
J. Exp. Med. 204 , 3017-3026 Antibody class switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double-stranded breaks (DSBs) in switch-region DNA. The initial steps in DSB formation have been elucidated, involving cytosine deamination by activation-... |
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A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.
Nucleic Acids Res. 39 , 3156-65, (2011) DNA repair is required to maintain genome stability in stem cells and early embryos. At critical junctures, oxidative damage to DNA requires the base excision repair (BER) pathway. Since early zebrafish embryos lack the major polymerase in BER, DNA polymerase... |