Dexrazoxane
Dexrazoxane structure
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Common Name | Dexrazoxane | ||
|---|---|---|---|---|
| CAS Number | 24584-09-6 | Molecular Weight | 268.269 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 531.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C11H16N4O4 | Melting Point | 194-196ºC | |
| MSDS | Chinese USA | Flash Point | 275.3±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Translational downregulation of HSP90 expression by iron chelators in neuroblastoma cells.
Mol. Pharmacol. 87(3) , 513-24, (2015) Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for the prom... |
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Doxorubicin impairs the insulin-like growth factor-1 system and causes insulin-like growth factor-1 resistance in cardiomyocytes.
PLoS ONE 10 , e0124643, (2015) Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R. Since cardio... |
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Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart.
PLoS ONE 9(10) , e109021, (2014) Multiple studies suggest creatine mediates anti-oxidant activity in addition to its established role in cellular energy metabolism. The functional significance for the heart has yet to be established, but antioxidant activity could contribute to the cardiopro... |
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Cytogenetic evidence that DNA topoisomerase II is not involved in radiation induced chromsome-type aberrations.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 793 , 14-8, (2015) ICRF-187 (Cardioxane™, Chiron) is a catalytic inhibitor of DNA topoisomerase II (Topo II), proposed to act by blocking Topo II-mediated DNA cleavage without stabilizing DNA-Topo II-"cleavable complexes". In this study ICRF-187 was used to evaluate the potenti... |
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Oxidative stress does not play a primary role in the toxicity induced with clinical doses of doxorubicin in myocardial H9c2 cells.
Mol. Cell Biochem. 413 , 199-215, (2016) The implication of oxidative stress as primary mechanism inducing doxorubicin (DOX) cardiotoxicity is still questionable as many in vitro studies implied supra-clinical drug doses or unreliable methodologies for reactive oxygen species (ROS) detection. The ai... |
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The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.
Br. J. Pharmacol. 172(9) , 2246-57, (2015) The catalytic topoisomerase II inhibitor dexrazoxane has been associated not only with improved cancer patient survival but also with secondary malignancies and reduced tumour response.We investigated the DNA damage response and the role of the activating tra... |
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Deferoxamine but not dexrazoxane alleviates liver injury induced by endotoxemia in rats.
Shock 42(4) , 372-9, (2014) The purpose of the present study was to compare the activity of two different clinically available iron chelators on the development of acute liver injury after administration of the bacterial endotoxin (lipopolysaccharide [LPS]) in rats. Lipopolysaccharide w... |
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Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomes.
J. Clin. Oncol. 30(10) , 1042-9, (2012) Doxorubicin causes cardiac injury and cardiomyopathy in children with acute lymphoblastic leukemia (ALL). Measuring biomarkers during therapy might help individualize treatment by immediately identifying cardiac injury and cardiomyopathy.Children with high-ri... |
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Savene® (dexrazoxane) use in clinical practice.
Support Care Cancer 20(5) , 1109-12, (2012) Anthracycline extravasation (ACEV) is a rare but potentially devastating event which can result in severe injuries including ulceration and necrosis, slow-healing lesions, serious joint damage and permanent disfigurement. It can delay further scheduled chemot... |
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Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training.
Am. J. Physiol. Heart Circ. Physiol. 302(10) , H2048-57, (2012) The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of childhood cancer. Specifically, doxorubicin (DOX) may be pa... |