4-Iodopyrazole
4-Iodopyrazole structure
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Common Name | 4-Iodopyrazole | ||
|---|---|---|---|---|
| CAS Number | 3469-69-0 | Molecular Weight | 193.97 | |
| Density | 2.3±0.1 g/cm3 | Boiling Point | 291.9±13.0 °C at 760 mmHg | |
| Molecular Formula | C3H3IN2 | Melting Point | 108-110 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 130.3±19.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences.
J. Mol. Biol. 239(3) , 415-29, (1994) The three-dimensional structures of three variants of human beta alcohol dehydrogenase have been determined to 2.5 A resolution. These three structures differ only in the amino acid at position 47 and the molecules occupying the alcohol binding site. Human be... |
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The effects of caffeic acid phenethyl ester in acute methanol toxicity on rat retina and optic nerve.
Cutan. Ocul. Toxicol. 32(4) , 263-7, (2013) We aimed to test caffeic acid phenethyl ester (CAPE) as an antidote for acute methanol (MeOH) toxicity and to compare it with ethanol.This study included five groups, each containing eight rats. The groups were control, methotrexate (MTX), MeOH, ethanol and C... |
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Indium-mediated synthesis of heterobiaryls.
J. Org. Chem. 72 , 3589, (2007) The palladium-mediated coupling reaction between triorganoindium reagents and organic electrophiles is extended to the synthesis of heteroaromatic compounds. Both electron-rich and electron-poor heterocycles can act as the organic electrophile or as the organ... |
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Some iodinated pyrazole derivatives.
J. Chem. Soc. Perkin Trans. I 13 , 1179-84, (1966)
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Synthesis of pyrazoles via electrophilic cyclization.
J. Org. Chem. 76(16) , 6726-42, (2011) Electrophilic cyclizations of α,β-alkynic hydrazones by molecular iodine were investigated for the synthesis of 4-iodopyrazoles. α,β-Alkynic hydrazones were readily prepared by the reactions of hydrazines with propargyl aldehydes and ketones. When treated wit... |
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Pyrazole binding in crystalline binary and ternary complexes with liver alcohol dehydrogenase.
Biochemistry 21(20) , 4858-66, (1982) Pyrazole is a strong inhibitor of liver alcohol dehydrogenase in combination with oxidized coenzyme NAD+. We have studied three different complexes of the inhibitor with the enzyme by using crystallographic methods: (1) the binary complex with pyrazole to 3.2... |
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Inducibility of P450Coh by pyrazole and its derivatives.
Biochem. Pharmacol. 42(9) , 1751-9, (1991) Pyrazole and several of its derivatives increase the hepatic microsomal coumarin 7-hydroxylase to a variable extent. The strongest inducers are pyrazole itself and those derivatives which have a hydroxy group or a halogen at the 4-position of the molecule. Th... |
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Induction of CYP2A5 by pyrazole and its derivatives in mouse primary hepatocytes.
Arch. Toxicol. 72(6) , 336-41, (1998) Mouse liver CYP2A5 is induced by several structurally unrelated compounds. In intact mouse liver, pyrazole (PYR) and 4-hydroxypyrazole (4-OH) induce selectively the expression of CYP2A5 while expression of other CYPs is decreased. In this study we exposed mou... |
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Axial ligand complexes of the Rhodnius nitrophorins: reduction potentials, binding constants, EPR spectra, and structures of the 4-iodopyrazole and imidazole complexes of NP4.
J. Biol. Inorg. Chem. 9(2) , 135-44, (2004) Previously, we utilized 4-iodopyrazole (4IPzH) as a heavy atom derivative for the initial solution of the crystal structure of the nitrophorin from Rhodnius prolixus, NP1, where it was found to bind to the heme with the iodo group disordered in two positions.... |
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Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.
J. Cancer Res. Clin. Oncol. 113(2) , 145-50, (1987) Using a hybrid ion-exchange reverse phase HPLC system, we found that F344 rat liver microsomes, in the presence of an NADPH-generating system, can metabolize methylazoxymethanol (MAM), a colon and liver carcinogen, to methanol and formic acid. This is in cont... |