1-Nitronaphthalene
1-Nitronaphthalene structure
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Common Name | 1-Nitronaphthalene | ||
|---|---|---|---|---|
| CAS Number | 86-57-7 | Molecular Weight | 173.16800 | |
| Density | 1.223 g/mL at 25 °C(lit.) | Boiling Point | 304 °C(lit.) | |
| Molecular Formula | C10H7NO2 | Melting Point | 56 °C | |
| MSDS | Chinese USA | Flash Point | 164 °C | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Combination of precolumn nitro-reduction and ultraperformance liquid chromatography with fluorescence detection for the sensitive quantification of 1-nitronaphthalene, 2-nitrofluorene, and 1-nitropyrene in meat products.
J. Agric. Food Chem. 63(12) , 3161-7, (2015) Carcinogenic nitropolycyclic aromatic hydrocarbons (nitro-PAHs) are ubiquitous in the ambient environment. They are emitted predominantly from internal combustion engines and by reacting polycyclic aromatic hydrocarbons with nitrogen oxide. The emerging evide... |
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Determination of trace level genotoxic impurities in small molecule drug substances using conventional headspace gas chromatography with contemporary ionic liquid diluents and electron capture detection.
J. Chromatogr. A. 1361 , 217-28, (2014) Ionic liquids (ILs) were used as a new class of diluents for the analysis of two classes of genotoxic impurities (GTIs), namely, alkyl/aryl halides and nitro-aromatics, in small molecule drug substances by headspace gas chromatography (HS-GC) coupled with ele... |
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Nitropolycyclic aromatic hydrocarbons are inducers of mitotic homologous recombination in the wing-spot test of Drosophila melanogaster.
Food Chem. Toxicol. 46(7) , 2344-8, (2008) In this study, the widespread environmental pollutants 1-nitronaphthalene (1NN), 1,5-dinitronaphthalene (1,5DNN), 2-nitrofluorene (2NF) and 9-nitroanthracene (9NA), were investigated for genotoxicity in the wing somatic mutation and recombination test (SMART)... |
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Selective detection of nitrated polycyclic aromatic hydrocarbons by electrospray ionization mass spectrometry and constant neutral loss scanning.
Rapid Commun. Mass Spectrom. 14(16) , 1474-81, (2000) The development of a method for selective detection of nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) among other polycyclic aromatic compounds (PACs) is described. The method is based on electrospray ionization mass spectrometry (ESI-MS), performed w... |
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Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes.
Mutat. Res. 608(1) , 88-96, (2006) 2,4-Diaminotoluene (2,4-DAT) is a liver carcinogen in rats and mice whereas 2,6-DAT is not. Both are genotoxic in vitro. Tests for mutations in transgenic mice, unscheduled DNA synthesis (UDS), DNA damage and enhancement of initiated foci in vivo have shown s... |
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The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways.
Environ. Health Perspect. 114(9) , 1354-60, (2006) Ambient air is polluted with a mixture of pulmonary toxicants. Previous studies indicate that prior exposure to atmospheric oxidant pollutants such as ozone may significantly alter the response to other pollutants, such as 1-nitronaphthalene (1-NN) . 1-NN, a ... |
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Increased vulnerability of neonatal rats and mice to 1-nitronaphthalene-induced pulmonary injury.
Toxicol. Appl. Pharmacol. 201(1) , 53-65, (2004) The postnatal period of lung development is a critical window of susceptibility to environmental toxicants, including polyaromatic hydrocarbons (PAHs) and furans. To determine whether the increased susceptibility of neonatal lung injury due to environmental t... |
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Identification of proteins adducted by reactive metabolites of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.
Proteomics 6(3) , 972-82, (2006) Naphthalene and 1-nitronaphthalene are ambient air pollutants, which undergo P450-dependent bioactivation in the lung. Reactive metabolites of naphthalene and 1-nitronaphthalene covalently bind to proteins, and the formation of covalent adducts correlates wit... |
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Site-specific metabolism of naphthalene and 1-nitronaphthalene in dissected airways of rhesus macaques.
J. Pharmacol. Exp. Ther. 310(2) , 546-54, (2004) Studies in rodents have demonstrated the importance of cytochrome P450 monooxygenases in generating reactive metabolites that produce Clara cell injury. Pulmonary P450 activities in rodents are much higher than those in primates, raising the issue of relevanc... |
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Long-term exposure to ozone increases acute pulmonary centriacinar injury by 1-nitronaphthalene: II. Quantitative histopathology.
J. Pharmacol. Exp. Ther. 295(3) , 942-50, (2000) Long-term exposure to the oxidant air pollutant ozone (O(3)) is associated with tolerance to the acute effects of oxidant injury. To test whether this resistance to acute injury extends to bioactivated pulmonary toxicants, male Sprague-Dawley rats were expose... |