Uracil
Uracil structure
|
Common Name | Uracil | ||
|---|---|---|---|---|
| CAS Number | 66-22-8 | Molecular Weight | 112.087 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 440.5±37.0 °C at 760 mmHg | |
| Molecular Formula | C4H4N2O2 | Melting Point | 330°C | |
| MSDS | Chinese USA | Flash Point | 220.2±26.5 °C | |
|
Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use.
J. Pharm. Biomed. Anal. 98 , 446-62, (2014) The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in the situation of commercial formulations for clinical use, namely FU dissolved in sodium hydroxide (NaOH) solutions or Tris buffer at pH 8.5-9. Combination of data f... |
|
|
The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer.
Cancer Epidemiol. Biomarkers Prev. 23(11) , 2328-37, (2014) Although colorectal cancer is a disease characterized by sequential accumulation of mutations in epithelial cells, mechanisms leading to genomic vulnerability contributing to tumor initiation remain undefined. GUCY2C has emerged as an intestine-specific tumor... |
|
|
Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase.
Biochem. Biophys. Res. Commun. 453(3) , 642-7, (2014) When mRNAs lack stop codons, errors in gene expression and coding of aberrant proteins that are harmful in cells can result. In Saccharomyces cerevisiae, a 180-kDa E3-ubiquitin ligase, Ltn1 has been known to associate with ribosomes and marks translationally-... |
|
|
Single gene insertion drives bioalcohol production by a thermophilic archaeon.
Proc. Natl. Acad. Sci. U. S. A. 111(49) , 17618-23, (2014) Bioethanol production is achieved by only two metabolic pathways and only at moderate temperatures. Herein a fundamentally different synthetic pathway for bioalcohol production at 70 °C was constructed by insertion of the gene for bacterial alcohol dehydrogen... |
|
|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
|
|
Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer.
Clin. Cancer Res. 21 , 3061-70, (2015) Serum PSA (sPSA) testing has led to the identification of patients with indolent prostate cancer, and inevitably overtreatment has become a concern. Progensa PCA3 urine testing was shown to improve the diagnosis of prostate cancer, but its diagnostic value fo... |
|
|
Pyrimidine homeostasis is accomplished by directed overflow metabolism.
Nature 500(7461) , 237-41, (2013) Cellular metabolism converts available nutrients into usable energy and biomass precursors. The process is regulated to facilitate efficient nutrient use and metabolic homeostasis. Feedback inhibition of the first committed step of a pathway by its final prod... |
|
|
Repetitive injection method: a tool for investigation of injection zone formation and its compression in microfluidic liquid chromatography.
J. Chromatogr. A. 1381 , 110-7, (2015) Sample introduction in microfluidic liquid chromatography often generates wide zones rather than peaks, especially when a large sample volume (relative to column volume) is injected. Formation of wide injection zones can be further amplified when the sample i... |
|
|
Adsorption of water from aqueous acetonitrile on silica-based stationary phases in aqueous normal-phase liquid chromatography.
J. Chromatogr. A. 1374 , 102-11, (2014) Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with differ... |
|
|
Wide injection zone compression in gradient reversed-phase liquid chromatography.
J. Chromatogr. A. 1390 , 86-94, (2015) Chromatographic zone broadening is a common issue in microfluidic chromatography, where the sample volume introduced on column often exceeds the column void volume. To better understand the propagation of wide chromatographic zones on a separation device, a s... |