Metformin HCl
Metformin HCl structure
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Common Name | Metformin HCl | ||
|---|---|---|---|---|
| CAS Number | 1115-70-4 | Molecular Weight | 165.625 | |
| Density | N/A | Boiling Point | 224.1ºC at 760 mmHg | |
| Molecular Formula | C4H12ClN5 | Melting Point | 223-226 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 89.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Differential effects of AMPK agonists on cell growth and metabolism.
Oncogene 34 , 3627-39, (2015) As a sensor of cellular energy status, the AMP-activated protein kinase (AMPK) is believed to act in opposition to the metabolic phenotypes favored by proliferating tumor cells. Consequently, compounds known to activate AMPK have been proposed as cancer thera... |
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Fermentation of Green Tea with 2% Aquilariae lignum Increases the Anti-Diabetic Activity of Green Tea Aqueous Extracts in the High Fat-Fed Mouse.
Nutrients 7 , 9046-78, (2015) Anti-diabetic effects on the metabolomic differences between green tea (GT) and Aquilariae lignum-fermented green tea (fGT) were investigated in the high fat-fed mouse. To prove the differences, hypoglycemic (blood glucose, insulin and glycated hemoglobin lev... |
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Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.
FEBS Lett. 589 , 1847-54, (2015) UNC-51 like kinase (ULK1) translocates to dysfunctional mitochondria and is involved in mitophagy, but the mechanisms responsible for ULK1 activation and translocation remain unclear. Here, we found that hypoxia induces phosphorylation of ULK1 at Serine-555 b... |
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N(1)-methylnicotinamide as an endogenous probe for drug interactions by renal cation transporters: studies on the metformin-trimethoprim interaction.
Eur. J. Clin. Pharmacol. 71(1) , 85-94, (2015) N(1)-methylnicotinamide (NMN) was proposed as an in vivo probe for drug interactions involving renal cation transporters, which, for example, transport the oral antidiabetic drug metformin, based on a study with the inhibitor pyrimethamine. The role of NMN fo... |
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Development and validation of fast and simple flow injection analysis-tandem mass spectrometry (FIA-MS/MS) for the determination of metformin in dog serum.
J. Pharm. Biomed. Anal. 107 , 229-35, (2015) A simple, fast and sensitive quantification method for the drug metformin in dog serum was developed using flow injection analysis (FIA)-tandem mass spectrometry (MS/MS). The method was fully validated according to industry standards. It is the first time tha... |
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Simultaneous determination of metformin and vildagliptin in human plasma by a HILIC-MS/MS method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 965 , 133-41, (2014) The objective of this work was to develop and validate a HILIC-MS/MS method for the simultaneous determination of metformin and vildagliptin in human plasma. Chromatographic separation was achieved using an Atlantis HILIC Silica 150-mm × 2.1-mm, 3-μm particle... |
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Monitoring and removal of residual phthalate esters and pharmaceuticals in the drinking water of Kaohsiung City, Taiwan.
J. Hazard. Mater. 277 , 53-61, (2014) This study monitored the occurrence and removal efficiencies of 8 phthalate esters (PAEs) and 13 pharmaceuticals present in the drinking water of Kaohsiung City, Taiwan. The simultaneous electrocoagulation and electrofiltration (EC/EF) process was used to rem... |
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Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis.
Nat. Commun. 6 , 7101, (2015) Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic and clinical data with a human metabolic network and find tha... |
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Large volume sample stacking for rapid and sensitive determination of antidiabetic drug metformin in human urine and serum by capillary electrophoresis with contactless conductivity detection.
J. Chromatogr. A. 1345 , 207-11, (2014) Two CE methods with contactless conductivity detection have been developed for determining the oral antidiabetic drug metformin in human urine and blood. The determination of metformin is performed on a separation capillary with an effective length of 14 cm, ... |
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AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Nat. Commun. 6 , 7176, (2015) Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and... |