4-Chloro-1-butanol
4-Chloro-1-butanol structure
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Common Name | 4-Chloro-1-butanol | ||
|---|---|---|---|---|
| CAS Number | 928-51-8 | Molecular Weight | 108.567 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 178.5±0.0 °C at 760 mmHg | |
| Molecular Formula | C4H9ClO | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 77.2±18.0 °C | |
| Symbol |
GHS02, GHS05, GHS07, GHS08 |
Signal Word | Warning | |
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Reichardt's dye and its reactions with the alkylating agents 4-chloro-1-butanol, ethyl methanesulfonate, 1-bromobutane and Fast Red B - a potentially useful reagent for the detection of genotoxic impurities in pharmaceuticals.
J. Pharm. Pharmacol. 61(4) , 533-7, (2009) Alkylating agents are potentially genotoxic impurities that may be present in drug products. These impurities occur in pharmaceuticals as by-products from the synthetic steps involved in drug production, as impurities in starting materials or from in-situ rea... |
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Development and validation of a sensitive GC-MS method for the determination of alkylating agent, 4-chloro-1-butanol, in active pharmaceutical ingredients.
Chem. Pharm. Bull. 62(4) , 395-8, (2014) The analysis of genotoxic impurities (GTIs) in active pharmaceutical ingredients (APIs) is a challenging task. The target detection limit (DL) in an API is typically around 1 ppm (1 µg/g API). Therefore, a sensitive and selective analytical method is required... |
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