2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
2,2'-Methylenebis(6-tert-butyl-4-methylphenol) structure
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Common Name | 2,2'-Methylenebis(6-tert-butyl-4-methylphenol) | ||
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| CAS Number | 119-47-1 | Molecular Weight | 340.499 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 428.6±40.0 °C at 760 mmHg | |
| Molecular Formula | C23H32O2 | Melting Point | 123-127 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 181.2±21.9 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).
Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012) The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in transit through the secretory pathway. Ca(2+) in the Golgi appar... |
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Effects of four bisphenolic antioxidants on lipid contents of rat liver.
Toxicol. Lett. 8(1-2) , 77-86, (1981) Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylphenol) or 4,4'-methylenebis(2,6-di-tert-butylphenol) at a le... |
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Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).
Biochem. Soc. Trans. 21(2) , 106S, (1993)
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Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2'-methylenebis(4-methyl-6-tert-butylphenol) in rats.
J. Toxicol. Sci. 19(2) , 77-88, (1994) General toxicity studies on 2,2'-methylenebis(4-methyl-6-tert-butylphenol) (MBMBP) were conducted using male and female Wistar rats. LD50 values were greater than 5 g/kg BW by oral administration for both sexes. Diarrhea was observed until 5 days. In the subc... |
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[Studies on the teratogenic potential of 2,2'-methylenebis (4-methyl-6-tert-butylphenol) in rats].
Eisei Shikenjo Hokoku. (108) , 52-7, (1990) 2,2'-Methylenebis (4-methyl-6-tert-butylphenol), an antioxidant, was given orally to pregnant Wistar rats by stomach intubation at the dose levels of 93.5, 187 or 375 mg/kg body weight during days 7 to 17 of pregnancy, and the effects of the compound on dams ... |
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Characterisation of a novel Ca2+ pump inhibitor (bis-phenol) and its effects on intracellular Ca2+ mobilization.
Biochim. Biophys. Acta 1195(2) , 252-8, (1994) Bis-phenol, a phenolic antioxidant, is an inhibitor of sarcoplasmic reticulum (SR), endoplasmic reticulum (ER) and plasma membrane Ca2+ ATPases. The concentration of bis-phenol giving half-maximal inhibition of the SR Ca(2+)-ATPase is 2 microM. On binding to ... |
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Secretory pathway Ca(2+)-ATPase (SPCA1) Ca(2)+ pumps, not SERCAs, regulate complex [Ca(2+)](i) signals in human spermatozoa.
J. Cell Sci. 118(Pt 8) , 1673-85, (2005) The sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase (SERCA) inhibitors thapsigargin (0.1-1 microM) and cyclopiazonic acid (10 microM), failed to affect resting [Ca(2+)] in human spermatozoa. Slow progesterone-induced [Ca(2+ i)](i) oscillations in human sperm... |
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GERI-BP002-A, novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus F93.
J. Antibiot. 49(1) , 31-6, (1996) A new inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), designated GERI-BP002-A, was isolated from the culture broth of Aspergillus fumigatus F93 by acetone extraction, EtOAc extraction, SiO2 column chromatography and reverse phase HPLC. Spectroscopic... |