2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

Modify Date: 2025-08-20 14:27:42

2,2'-Methylenebis(6-tert-butyl-4-methylphenol) structure	Common Name	2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
	CAS Number	119-47-1	Molecular Weight	340.499
	Density	1.0±0.1 g/cm3	Boiling Point	428.6±40.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₃₂O₂	Melting Point	123-127 °C(lit.)
	MSDS	Chinese USA	Flash Point	181.2±21.9 °C
	Symbol	GHS08	Signal Word	Warning

Name	2,2-Methylenebis(6-Tert-Butyl-4-Methylphenol)
Synonym	More Synonyms

Density	1.0±0.1 g/cm3
Boiling Point	428.6±40.0 °C at 760 mmHg
Melting Point	123-127 °C(lit.)
Molecular Formula	C₂₃H₃₂O₂
Molecular Weight	340.499
Flash Point	181.2±21.9 °C
Exact Mass	340.240234
PSA	40.46000
LogP	7.03
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.551

MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PA3500000

CHEMICAL NAME :: Methane, 2,2'-bis(6-t-butyl-p-cresyl)-

CAS REGISTRY NUMBER :: 119-47-1

BEILSTEIN REFERENCE NO. :: 2062676

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C23-H32-O2

MOLECULAR WEIGHT :: 340.55

WISWESSER LINE NOTATION :: 1X1&1&R BQ C3R BQ CX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,240,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(8),28,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1623 mg/kg/1W-C

TOXIC EFFECTS :: Liver - other changes Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 25200 mg/kg/12W-C

TOXIC EFFECTS :: Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23096 mg/kg/78W-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

REFERENCE :: JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82995 No. of Facilities: 275 (estimated) No. of Industries: 6 No. of Occupations: 23 No. of Employees: 5131 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82995 No. of Facilities: 6941 (estimated) No. of Industries: 70 No. of Occupations: 72 No. of Employees: 150745 (estimated) No. of Female Employees: 36237 (estimated)

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H361f-H413
Precautionary Statements	P281
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	PA3500000
HS Code	29072900

Formaldehyde

CAS#:50-00-0

2-tert-Butyl-4-...

CAS#:2409-55-4

~84%

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Casiraghi, Giovanni; Casnati, Giuseppe; Pochini, Andrea; Puglia, Giuseppe; Ungaro, Rocco; Sartori, Giovanni Synthesis, 1981 , # 2 p. 143 - 146

Formaldehyde

CAS#:50-00-0

2,4-Di-t-butylphenol

CAS#:96-76-4

~78%

2,2'-methyleneb...

CAS#:14362-12-0

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Synthetic Communications, , vol. 42, # 24 p. 3670 - 3676,7 Synthetic Communications, , vol. 42, # 24 p. 3670 - 3676

dimethoxymethane

CAS#:109-87-5

2-tert-Butyl-4-...

CAS#:2409-55-4

Sulfuric acid

CAS#:7664-93-9

2,2'-Methyleneb...

CAS#:119-47-1

Literature: US4087469 A1, ;

6-tert-butyl-2-...

CAS#:27996-19-6

6-T-BUTYL-2-MET...

CAS#:2219-82-1

2,4-Xylenol, 6-...

CAS#:1879-09-0

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Russian Journal of General Chemistry, , vol. 79, # 6 p. 1156 - 1162

Formaldehyde

CAS#:50-00-0

p-Cresol

CAS#:106-44-5

Methyl tert-but...

CAS#:1634-04-4

~99%

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Fareghi-Alamdari, Reza; Golestanzadeh, Mohsen; Agend, Farima; Zekri, Negar Canadian Journal of Chemistry, 2013 , vol. 91, # 10 p. 982 - 991

p-Cresol

CAS#:106-44-5

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 159, p. 155,157, 166 Chemische Berichte, , vol. 74, p. 1539,1543

dimethoxymethane

CAS#:109-87-5

2-tert-Butyl-4-...

CAS#:2409-55-4

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Journal of Organic Chemistry USSR (English Translation), , p. 1364 - 1368 Zhurnal Organicheskoi Khimii, , vol. 21, # 7 p. 1496 - 1501

2-tert-Butyl-4-...

CAS#:2409-55-4

N/A

CAS#:4103-77-9

2,2'-Methyleneb...

CAS#:119-47-1

Literature: Journal of Organic Chemistry USSR (English Translation), , p. 1364 - 1368 Zhurnal Organicheskoi Khimii, , vol. 21, # 7 p. 1496 - 1501

dimethoxymethane

CAS#:109-87-5

2-tert-Butyl-4-...

CAS#:2409-55-4

2,2'-Methyleneb...

CAS#:119-47-1

N/A

CAS#:4103-77-9

Literature: Journal of Organic Chemistry USSR (English Translation), , vol. 21, # 3 p. 553 - 555 Zhurnal Organicheskoi Khimii, , vol. 21, # 3 p. 611 - 613

Precursor 8
CAS#:50-00-0 Formaldehyde CAS#:2409-55-4 2-tert-Butyl-4-... CAS#:96-76-4 2,4-Di-t-butylphenol CAS#:109-87-5 dimethoxymethane
CAS#:7664-93-9 Sulfuric acid CAS#:27996-19-6 6-tert-butyl-2-... CAS#:106-44-5 p-Cresol CAS#:1634-04-4 Methyl tert-but...
DownStream 8
CAS#:3236-63-3 4,4'-dimethylme... CAS#:2409-55-4 2-tert-Butyl-4-... CAS#:34573-99-4 1,9-ditert-buty... CAS#:1879-09-0 2,4-Xylenol, 6-...
CAS#:109-89-7 Diethylamine CAS#:295805-67-3 bis[3-tert-buty... CAS#:61167-58-6 2-(1,1-dimethyl... CAS#:61167-60-0 2-Methylacrylic...

HS Code	29072900

Bis(2-hydroxy-3-tert-butyl-5-methyl-phenyl)-methane (bis-phenol) is a potent and selective inhibitor of the secretory pathway Ca²⁺ ATPase (SPCA1).

Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012)

The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in trans...

Effects of four bisphenolic antioxidants on lipid contents of rat liver.

Toxicol. Lett. 8(1-2) , 77-86, (1981)

Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...

Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).

Biochem. Soc. Trans. 21(2) , 106S, (1993)

MFCD00043641

2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol

Cyanox 2246

2,2'-Methylenebis[4-methyl-6-(2-methyl-2-propanyl)phenol]

3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane

2,2'-Methylenebis(6-tert-butyl-p-cresol)

Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-

EINECS 204-327-1

p-Cresol, 2,2'-methylenebis[6-tert-butyl-

2,2'-Methylene-bis-(4-methyl-6-tert-butyl-phenol)

6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)

2,2'-methylenebis(6-tert-butyl-4-methylphenol)

Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane

bis-[2-hydroxy-5-methyl-3-tert-butylphenyl]-methane

1X1&1&R BQ E1 C1R BQ E1 CX1&1&1

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China
Product Name: 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
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China
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China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Methylenebis
Price: ￥Inquiry/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
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Email: 3096638339@qq.com

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Price: ￥128/100g

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2,2'-Methylenebis(6-tert-butyl-4-methylphenol)

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles8

Synonyms

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