2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
Names
[ CAS No. ]:
119-47-1
[ Name ]:
2,2'-Methylenebis(6-tert-butyl-4-methylphenol)
[Synonym ]:
MFCD00043641
2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol
Cyanox 2246
2,2'-Methylenebis[4-methyl-6-(2-methyl-2-propanyl)phenol]
3,3'-Di-tert-butyl-2,2'-dihydroxy-5,5'-dimethyldiphenylmethane
2,2'-Methylenebis(6-tert-butyl-p-cresol)
Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-
EINECS 204-327-1
p-Cresol, 2,2'-methylenebis[6-tert-butyl-
2,2'-Methylene-bis-(4-methyl-6-tert-butyl-phenol)
6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)
2,2'-methylenebis(6-tert-butyl-4-methylphenol)
Bis(3-tert-butyl-2-hydroxy-5-methylphenyl)methane
bis-[2-hydroxy-5-methyl-3-tert-butylphenyl]-methane
1X1&1&R BQ E1 C1R BQ E1 CX1&1&1
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
428.6±40.0 °C at 760 mmHg
[ Melting Point ]:
123-127 °C(lit.)
[ Molecular Formula ]:
C23H32O2
[ Molecular Weight ]:
340.499
[ Flash Point ]:
181.2±21.9 °C
[ Exact Mass ]:
340.240234
[ PSA ]:
40.46000
[ LogP ]:
7.03
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.551
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PA3500000
- CHEMICAL NAME :
- Methane, 2,2'-bis(6-t-butyl-p-cresyl)-
- CAS REGISTRY NUMBER :
- 119-47-1
- BEILSTEIN REFERENCE NO. :
- 2062676
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C23-H32-O2
- MOLECULAR WEIGHT :
- 340.55
- WISWESSER LINE NOTATION :
- 1X1&1&R BQ C3R BQ CX1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,240,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 38(8),28,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 11 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1623 mg/kg/1W-C
- TOXIC EFFECTS :
- Liver - other changes Blood - changes in other cell count (unspecified) Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 8,77,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25200 mg/kg/12W-C
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 23096 mg/kg/78W-C
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
- REFERENCE :
- JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 19,77,1994 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82995 No. of Facilities: 275 (estimated) No. of Industries: 6 No. of Occupations: 23 No. of Employees: 5131 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82995 No. of Facilities: 6941 (estimated) No. of Industries: 70 No. of Occupations: 72 No. of Employees: 150745 (estimated) No. of Female Employees: 36237 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H361f-H413
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
PA3500000
[ HS Code ]:
29072900
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 29072900
Articles
Biochem. Biophys. Res. Commun. 424(3) , 616-9, (2012)
The secretory pathway Ca(2+) ATPase (SPCA) provides the Golgi apparatus with a Ca(2+) supply essential for Ca(2+)-dependent enzymes involved in the post-translational modification of proteins in trans...
Effects of four bisphenolic antioxidants on lipid contents of rat liver.Toxicol. Lett. 8(1-2) , 77-86, (1981)
Hepatic lipids were studied in Sprague-Dawley male rats given, 2,2'-methylenebis(4-ethyl-6-tert-butylphenol), 2,2'-methylenebis(4-methyl-6-tert-butylphenol), 4,4'-butylidenebis(3-methyl-6-tert-butylph...
Inhibition of the sarcoplasmic and endoplasmic calcium pump by bis(2-hydroxy-3-tert-butyl-5-methyl)methane, (bis-phenol).Biochem. Soc. Trans. 21(2) , 106S, (1993)