Zaleplon
Zaleplon structure
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Common Name | Zaleplon | ||
|---|---|---|---|---|
| CAS Number | 151319-34-5 | Molecular Weight | 305.334 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C17H15N5O | Melting Point | 186-1870C | |
| MSDS | Chinese USA | Flash Point | 48.2 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834.
Drug Metab. Dispos. 43 , 908-15, (2015) GDC-0834, a Bruton's tyrosine kinase inhibitor investigated as a potential treatment of rheumatoid arthritis, was previously reported to be extensively metabolized by amide hydrolysis such that no measurable levels of this compound were detected in human circ... |
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GABAA-positive modulator selective discriminative stimulus effects of 1,1,1-trichloroethane vapor.
Drug Alcohol Depend. 121(1-2) , 103-9, (2012) The abuse-related behavioral effects of inhalant vapors are poorly understood but probably involve multiple neurotransmitter receptor mechanisms. The present study examined the receptor systems responsible for transducing the discriminative stimulus of the ab... |
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Comparison of triazolam and zaleplon for sedation of dental patients.
Dent. Today 24(9) , 64-6, 68-9, (2005)
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Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications.
Expert Opin. Drug Metab. Toxicol. 8(12) , 1609-18, (2012) Eszopiclone is the active S-enantiomer of R,S-zopiclone, and is a cyclopyrrolone hypnotic acting via the GABA-benzodiazepine receptor system. Nearly 6 million prescriptions for eszopiclone are written yearly in the United States.This paper addresses the pharm... |
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Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
Pharmacol. Biochem. Behav. 104 , 62-8, (2013) The present studies evaluated the role of α1 and α5 subunit-containing GABAA receptors (α1GABAA and α5GABAA receptors, respectively) in the ability of benzodiazepine (BZ)-type drugs to alter performance in the cognitive domain of executive function. Five adul... |
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Sleep aid toxicosis in dogs: 317 cases (2004-2010).
J. Vet. Emerg. Crit. Care (San Antonio.) 21(6) , 658-65, (2011) To summarize the signalment, clinical signs observed, time to onset of clinical signs, duration of clinical signs, and the outcome in a large case series of nonbenzodiazepine sleep aid ingestions in dogs, including 2 sleep aids that have not been previously d... |
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Safety of zaleplon in the treatment of insomnia.
Ann. Pharmacother. 36(5) , 852-9, (2002) To evaluate the safety of zaleplon, a quick-acting, rapidly eliminated nonbenzodiazepine (non-BZD) hypnotic, as described in clinical investigations of adult and/or elderly subjects.Published and presented studies evaluating zaleplon, a novel non-BZD, were id... |
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Comparative analysis of zaleplon complexation with cyclodextrins and hydrophilic polymers in solution and in solid state.
J. Pharm. Biomed. Anal. 71 , 35-44, (2012) The aim of this work was to investigate the potential synergistic effect of water-soluble polymers (hypromellose, HPMC and polyvinylpyrrolidone, PVP) on zaleplon (ZAL) complexation with parent β-cyclodextrin (βCD) and its randomly methylated derivative (RAMEB... |
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Efficacy and safety of zaleplon at peak plasma levels.
Int. J. Clin. Pract. Suppl. (116) , 9-13, (2001) Zaleplon is a non-benzodiazepine sleep medication that shows efficacy as a sleep inducer comparable to that of other hypnotics but with significantly fewer residual effects. In addition, evaluations of psychomotor or memory function at zaleplon peak plasma le... |