Cetirizine Dihydrochloride
Cetirizine Dihydrochloride structure
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Common Name | Cetirizine Dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 83881-52-1 | Molecular Weight | 461.81 | |
| Density | 1.237 g/cm3 | Boiling Point | 542.1ºC at 760 mmHg | |
| Molecular Formula | C21H27Cl3N2O3 | Melting Point | 110-115ºC | |
| MSDS | Chinese USA | Flash Point | 281.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.
Microcirculation 22 , 237-48, (2015) The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated potential downstream signals.We used confluent EC monolayer... |
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Kinetics of the esterification of active pharmaceutical ingredients containing carboxylic acid functionality in polyethylene glycol: formulation implications.
J. Pharm. Sci. 103(8) , 2424-33, (2014) Polyethylene glycols (PEGs) are attractive as excipients in the manufacture of drug products because they are water soluble and poorly immunogenic. They are used in various pharmaceutical preparations. However, because of their terminal hydroxyl groups, PEGs ... |
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Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.
Gut 63(12) , 1873-82, (2014) Substantial evidence implicates mast cells and their main constituent histamine in the pathogenesis of visceral hypersensitivity. We explored the specific contribution of histamine H4 (H4R) and H1 (H1R) receptors to visceral hypersensitivity in a postinflamma... |
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Simultaneous analysis of vitamins B in pharmaceuticals and dietary supplements by capillary electrophoresis hyphenated with triple quadrupole mass spectrometry.
Pharmazie 69(9) , 663-8, (2014) The advanced hyphenated method based on capillary electrophoresis (CE) on-line combined with electrospray ionization (ESI) and tandem mass spectrometry (MS/MS, here triple quadrupole, QqQ) was developed and applied in pharmaceutical analysis in this work. Und... |
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Rapid chiral separation of racemic cetirizine in human plasma using subcritical fluid chromatography-tandem mass spectrometry.
J. Pharm. Biomed. Anal. 117 , 380-9, (2015) A method for fast chiral separation of cetirizine and quantitation of levocetirizine in human plasma using subcritical fluid chromatography with tandem mass spectrometry was developed and validated. The chromatographic separation was performed using a Chiralp... |
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Beneficial role for supplemental vitamin D3 treatment in chronic urticaria: a randomized study
Ann. Allergy Asthma Immunol. 112(4) , 376-82, (2014) Background Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. |
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Chronic pelvic allodynia is mediated by CCL2 through mast cells in an experimental autoimmune cystitis model.
Am. J. Physiol. Renal Physiol. 308(2) , F103-13, (2015) The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS) remains unclear; autoimmunity is a possible etiology. We have recently shown that injection of a single immunogenic peptide of uroplakin 3A (UPK3A 65-84) induces exper... |
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Modulation of tissue inflammatory response by histamine receptors in scorpion envenomation pathogenesis: involvement of H4 receptor.
Inflammation 37(5) , 1689-704, (2014) The inflammatory response caused by scorpion venoms is a key event in the pathogenesis of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and gastric tissues of envenomed mice. The results reveal an increase of permeability in car... |
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A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus.
Burns 39(1) , 24-9, (2013) Post-burn itch is a distressing symptom in burns rehabilitation and its treatment often proves frustrating for the patient and the multidisciplinary burns team. Traditionally, the mainstay of antipruritic therapy for decades has been antihistamines and massag... |
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H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.
Am. J. Physiol. Gastrointest. Liver Physiol. 307(2) , G219-28, (2014) We examined the effects of two over-the-counter H1-antihistamines on the progression of fatty liver disease in male C57Bl/6 wild-type and apolipoprotein E (ApoE)-/- mice. Mice were fed a high-fat diet (HFD) for 3 mo, together with administration of either cet... |